Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 윤지영 | * |
dc.date.accessioned | 2020-08-20T16:30:18Z | - |
dc.date.available | 2020-08-20T16:30:18Z | - |
dc.date.issued | 2019 | * |
dc.identifier.issn | 1011-6125 | * |
dc.identifier.issn | 1423-0372 | * |
dc.identifier.other | OAK-27623 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/255026 | - |
dc.description.abstract | Objective: This study aimed to describe the change in functional status following bilateral subthalamic nucleus stimulation (STN-DBS) in Parkinson's disease (PD) and to identify predictors of postoperative functional dependence. Methods: We included PD patients with bilateral STN-DBS who had complete Schwab & England Activities of Daily Living (S&E ADL) Scale data at baseline and 6 months after surgery from our prospective registry. Functional dependence was defined as an S&E ADL score of less than 80%. All data were collected from the on-medication state and on-stimulation state (after surgery). Logistic regression analyses were performed to determine the factors predictive of functional dependence after surgery. Results: A total of 196 patients were included. At baseline, 41 patients were functionally dependent and the other 155 were functionally independent. Among the patients with preoperative dependence, 32 (78%) became functionally independent after surgery, and this conversion was associated with a lower baseline axial score (p = 0.012). Among the patients with preoperative independence, 21 (14%) developed postoperative dependence, and this conversion was associated with a higher baseline axial score (p = 0.013) and its smaller improvement (p < 0.001). Female sex (odds ratio [OR] 3.214; 95% confidence interval [CI] 1.210-8.542; p = 0.019) and a higher baseline axial score (OR 1.184; 95% CI 1.056-1.327; p = 0.004) significantly predicted the risk of postoperative functional dependence. Conclusions: We found that functional status following bilateral STN-DBS is closely related to preoperative axial symptoms. When loss of independence is a potential target for STN-DBS, clinicians should take into consideration the severity of axial impairment before surgery. (C) 2019 S. Karger AG, Basel | * |
dc.language | English | * |
dc.publisher | KARGER | * |
dc.subject | Parkinson's disease | * |
dc.subject | Deep brain stimulation | * |
dc.subject | Activities of daily living | * |
dc.subject | Dependence | * |
dc.subject | Independence | * |
dc.title | Determinants of Functional Independence or Its Loss following Subthalamic Nucleus Stimulation in Parkinson's Disease | * |
dc.type | Article | * |
dc.relation.issue | 2 | * |
dc.relation.volume | 97 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 106 | * |
dc.relation.lastpage | 112 | * |
dc.relation.journaltitle | STEREOTACTIC AND FUNCTIONAL NEUROSURGERY | * |
dc.identifier.doi | 10.1159/000500277 | * |
dc.identifier.wosid | WOS:000481459200005 | * |
dc.author.google | Kim, Ryul | * |
dc.author.google | Yoo, Dallah | * |
dc.author.google | Jung, Yu Jin | * |
dc.author.google | Lee, Woong-Woo | * |
dc.author.google | Ehm, Gwanhee | * |
dc.author.google | Yun, Ji Young | * |
dc.author.google | Kim, Hee Jin | * |
dc.author.google | Lee, Jee-Young | * |
dc.author.google | Kim, Ji-Young | * |
dc.author.google | Kim, Han-Joon | * |
dc.author.google | Paek, Sun Ha | * |
dc.author.google | Jeon, Beomseok | * |
dc.contributor.scopusid | 윤지영(55216408300) | * |
dc.date.modifydate | 20240308141639 | * |