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Auranofin is an effective agent against clinical isolates of Staphylococcus aureus
- Title
- Auranofin is an effective agent against clinical isolates of Staphylococcus aureus
- Authors
- Tharmalingam, Nagendran; Ribeiro, Noelly Q.; da Silva, Danielle L.; Naik, Mandar T.; Cruz, Lana I. B.; Kim, Wooseong; Shen, Steven; dos Santos, Jessica D.; Ezikovich, Katarina; D'Agata, Erika M. C.; Mylonakis, Eleftherios; Fuchs, Beth B.
- Ewha Authors
- 김우성
- SCOPUS Author ID
- 김우성
- Issue Date
- 2019
- Journal Title
- FUTURE MEDICINAL CHEMISTRY
- ISSN
- 1756-8919
1756-8927
- Citation
- FUTURE MEDICINAL CHEMISTRY vol. 11, no. 12, pp. 1417 - 1425
- Keywords
- antimicrobial; auranofin; drug resistant bacteria; MRSA; Staphylococcus aureus; thioredoxin reductase; VISA
- Publisher
- FUTURE SCI LTD
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Aim: The orphan drug auranofin was recently found to exhibit antimicrobial properties. Materials & methods: We explored the efficacy of auranofin by evaluating the minimal inhibitory concentration against a collection of over 500 clinical isolates derived from multiple institutions, inclusive of drug resistant strains. Our evaluation also included continuous exposure of bacteria to auranofin. Results & conclusion: We found that minimal inhibitory concentrations ranged between 0.125 and 1 mg/l, exerting robust antimicrobial activity against a sizeable clinical collection of the bacteria. Further, we evaluated the propensity of the methicillin resistant Staphylococcus aureus strain MW2 to develop resistance through extended exposure to auranofin. After 25 days, the bacteria remained susceptible. Our data suggest that resistance mechanisms do not currently exist to block auranofin antimicrobial activity.
- DOI
- 10.4155/fmc-2018-0544
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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