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N-Acetyldopamine derivatives from Periostracum Cicadae and their regulatory activities on Th1 and Th17 cell differentiation
- Title
- N-Acetyldopamine derivatives from Periostracum Cicadae and their regulatory activities on Th1 and Th17 cell differentiation
- Authors
- Thapa, Punam; Gu, Ye; Kil, Yun-Seo; Baek, Su Cheol; Kim, Ki Hyun; Han, Ah-Reum; Seo, Eun Kyoung; Choi, Hyukjae; Chang, Jae-Hoon; Nam, Joo-Won
- Ewha Authors
- 서은경
- SCOPUS Author ID
- 서은경
- Issue Date
- 2020
- Journal Title
- BIOORGANIC CHEMISTRY
- ISSN
- 0045-2068
1090-2120
- Citation
- BIOORGANIC CHEMISTRY vol. 102
- Keywords
- Periostracum Cicadae; N-acetyldopamine dimers; H-1 iterative Full Spin Analysis (HiFSA); Electronic circular dichroism (ECD) calculation; CD4(+) T cell
- Publisher
- ACADEMIC PRESS INC ELSEVIER SCIENCE
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Bioassay-guided fractionation of a 90% ethanol extract of Periostracum Cicadae led to the isolation of two new N-acetyldopamine dimers (1a/1b) along with six known dimers (2a/2b, 3a/3b, and 4a/4b) and two monomers (5a/5b); compounds 2a/2b, 4a/4b and 5a/5b were newly isolated from this material. All compounds were isolated as enantiomeric mixtures and each enantiomer was successfully separated by chiral-phase HPLC. The structures including absolute configurations were confirmed by high-resolution electrospray ionization mass spectrometry (HR-ESIMS), 1D/2D nuclear magnetic resonance (NMR) spectroscopy, H-1 iterative Full Spin Analysis (HiFSA), and electronic circular dichroism (ECD) spectroscopy. Subsequently, the bioactivities of these isolates were evaluated via CD4(+) T cell differentiations, which are critical for immune responses and inflammation. The results revealed that compound 5b was observed to enhance the IFN-gamma(+) Th1 differentiation, which may have a potential for cancer immunotherapy.
- DOI
- 10.1016/j.bioorg.2020.104095
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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