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N-Acetyldopamine derivatives from Periostracum Cicadae and their regulatory activities on Th1 and Th17 cell differentiation

Title
N-Acetyldopamine derivatives from Periostracum Cicadae and their regulatory activities on Th1 and Th17 cell differentiation
Authors
Thapa P.Gu Y.Kil Y.-S.Baek S.C.Kim K.H.Han A.-R.Seo E.K.Choi H.Chang J.-H.Nam J.-W.
Ewha Authors
서은경
SCOPUS Author ID
서은경scopus
Issue Date
2020
Journal Title
Bioorganic Chemistry
ISSN
0045-2068JCR Link
Citation
Bioorganic Chemistry vol. 102
Keywords
1H iterative Full Spin Analysis (HiFSA)CD4+ T cellElectronic circular dichroism (ECD) calculationN-acetyldopamine dimersPeriostracum Cicadae
Publisher
Academic Press Inc.
Indexed
SCIE; SCOPUS scopus
Document Type
Article
Abstract
Bioassay-guided fractionation of a 90% ethanol extract of Periostracum Cicadae led to the isolation of two new N-acetyldopamine dimers (1a/1b) along with six known dimers (2a/2b, 3a/3b, and 4a/4b) and two monomers (5a/5b); compounds 2a/2b, 4a/4b and 5a/5b were newly isolated from this material. All compounds were isolated as enantiomeric mixtures and each enantiomer was successfully separated by chiral-phase HPLC. The structures including absolute configurations were confirmed by high-resolution electrospray ionization mass spectrometry (HR-ESIMS), 1D/2D nuclear magnetic resonance (NMR) spectroscopy, 1H iterative Full Spin Analysis (HiFSA), and electronic circular dichroism (ECD) spectroscopy. Subsequently, the bioactivities of these isolates were evaluated via CD4+ T cell differentiations, which are critical for immune responses and inflammation. The results revealed that compound 5b was observed to enhance the IFN-γ+ Th1 differentiation, which may have a potential for cancer immunotherapy. © 2020 Elsevier Inc.
DOI
10.1016/j.bioorg.2020.104095
Appears in Collections:
약학대학 > 약학과 > Journal papers
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