Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이지희 | * |
dc.contributor.author | 김희선 | * |
dc.contributor.author | 박진선 | * |
dc.contributor.author | 임예현 | * |
dc.date.accessioned | 2020-08-13T16:30:04Z | - |
dc.date.available | 2020-08-13T16:30:04Z | - |
dc.date.issued | 2020 | * |
dc.identifier.issn | 0753-3322 | * |
dc.identifier.issn | 1950-6007 | * |
dc.identifier.other | OAK-27319 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/254876 | - |
dc.description.abstract | Parkinson's disease (PD) is a neurodegenerative disorder characterized by motor impairments. Most PD drugs act by improving motor impairments, whereas very few drugs that efficiently recover PD-related neuropathological features, particularly alpha-synuclein-related toxicity, have been developed. In this study, we found that papaverine (PAP) attenuated behavioral deficits and protected against nigrostriatal dopaminergic degeneration in the subacute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/probenecid (MPTP/P) mouse model of PD. Histological analysis of tissue dissected from mice sacrificed nearly 3 weeks after the completion of treatment revealed that PAP significantly ameliorated microglia/astrocyte activation in the striatum and substantia nigra of MPTP/Ptreated mice. In addition, PAP diminished alpha-synuclein expression and aggregation in this model. Furthermore, PAP inhibited the phosphorylation of alpha-synuclein at serine 129, which may underlie the observed reduction in alpha-synuclein aggregation. PAP also reduced the expression of matrix metalloproteinase-3 (MMP-3), and the MMP3-positive area co-labeled with thioflavin-S. Taken together, our data suggest that PAP inhibits dopaminergic neuronal cell death and alpha-synuclein aggregation by suppressing neuroinflammation and MMP-3 expression in the subacute MPTP/P mouse model of PD. Accordingly, PAP may be a promising drug for the treatment of PD. | * |
dc.language | English | * |
dc.publisher | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER | * |
dc.subject | Parkinson's disease | * |
dc.subject | MPTP/probenecid | * |
dc.subject | alpha-Synuclein | * |
dc.subject | Neuroinflammation | * |
dc.subject | Matrix metalloproteinase-3 | * |
dc.subject | Papaverine | * |
dc.title | Papaverine inhibits alpha-synuclein aggregation by modulating neuroinflammation and matrix metalloproteinase-3 expression in the subacute MPTP/P mouse model of Parkinson's disease | * |
dc.type | Article | * |
dc.relation.volume | 130 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | BIOMEDICINE & PHARMACOTHERAPY | * |
dc.identifier.doi | 10.1016/j.biopha.2020.110576 | * |
dc.identifier.wosid | WOS:000582697900075 | * |
dc.identifier.scopusid | 2-s2.0-85089013794 | * |
dc.author.google | Leem, Yea-Hyun | * |
dc.author.google | Park, Jin-Sun | * |
dc.author.google | Park, Jung-Eun | * |
dc.author.google | Kim, Do-Yeon | * |
dc.author.google | Kang, Jihee Lee | * |
dc.author.google | Kim, Hee-Sun | * |
dc.contributor.scopusid | 이지희(7404517577) | * |
dc.contributor.scopusid | 김희선(57191372551) | * |
dc.contributor.scopusid | 박진선(54914743600) | * |
dc.contributor.scopusid | 임예현(25422269100) | * |
dc.date.modifydate | 20240222143226 | * |