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The effect of uric acid and urinary sodium excretion on prehypertension: a nationwide population-based study

Title
The effect of uric acid and urinary sodium excretion on prehypertension: a nationwide population-based study
Authors
Lee, ShinaChoi, Kyu BokKim, Seung-Jung
Ewha Authors
최규복김승정이신아
SCOPUS Author ID
최규복scopus; 김승정scopus; 이신아scopusscopus
Issue Date
2020
Journal Title
BMC CARDIOVASCULAR DISORDERS
ISSN
1471-2261JCR Link
Citation
BMC CARDIOVASCULAR DISORDERS vol. 20, no. 1
Keywords
PrehypertensionUric acidSodium
Publisher
BMC
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
BackgroundThis study examined the effect of serum uric acid (SUA) level and urinary sodium excretion on blood pressure as well as their combined effect on prehypertension in a Korean population.MethodData from the 7th Korea National Health and Nutrition Examination Survey for adults (>= 19years of age) were used. The participants were classified into two groups, normotension and prehypertension, according to the JNC-7 definition. Logistic regression was carried out and adjusted for traditionally regarded confounders of blood pressure. All analyses considered a complex sampling design. A multivariate analysis was performed on subgroups defined according to their SUA level and urinary sodium excretion.ResultsThe 4200 participants were divided into normotension (n=2646) and prehypertension (n=1554) groups. In the univariate analysis, patient age, male sex, concurrent comorbidity (diabetes mellitus, cardiovascular disease, stroke, dyslipidemia, and chronic kidney disease), uric acid, and urinary sodium excretion were associated with prehypertension. After adjusting for baseline covariates, both the SUA level and urinary sodium excretion were significant predictors of incident prehypertension (SUA, per 1mg/dL increase, odds ratio [OR] 1.216, 95% confidence interval [95% CI] 1.131-1.309; urinary sodium excretion, per 1g/day increase, OR 1.067, 95% CI 1.019-1.117). Additionally, simultaneously higher tertiles of SUA and urinary sodium excretion resulted in higher ORs for prehypertension.ConclusionIncreased SUA is a significant risk marker for the development of prehypertension in normotensives. Simultaneously high SUA and urinary sodium excretion amplified the effect on the development of prehypertension. Our findings suggest that lowering SUA levels and reducing sodium intake will contribute to preventing hypertension.
DOI
10.1186/s12872-020-01535-9
Appears in Collections:
의과대학 > 의학과 > Journal papers
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