View : 116 Download: 0
The effect of uric acid and urinary sodium excretion on prehypertension: a nationwide population-based study
- The effect of uric acid and urinary sodium excretion on prehypertension: a nationwide population-based study
- Lee, Shina; Choi, Kyu Bok; Kim, Seung-Jung
- Ewha Authors
- 최규복; 김승정; 이신아
- SCOPUS Author ID
- 최규복; 김승정; 이신아
- Issue Date
- Journal Title
- BMC CARDIOVASCULAR DISORDERS
- BMC CARDIOVASCULAR DISORDERS vol. 20, no. 1
- Prehypertension; Uric acid; Sodium
- SCIE; SCOPUS
- Document Type
- BackgroundThis study examined the effect of serum uric acid (SUA) level and urinary sodium excretion on blood pressure as well as their combined effect on prehypertension in a Korean population.MethodData from the 7th Korea National Health and Nutrition Examination Survey for adults (>= 19years of age) were used. The participants were classified into two groups, normotension and prehypertension, according to the JNC-7 definition. Logistic regression was carried out and adjusted for traditionally regarded confounders of blood pressure. All analyses considered a complex sampling design. A multivariate analysis was performed on subgroups defined according to their SUA level and urinary sodium excretion.ResultsThe 4200 participants were divided into normotension (n=2646) and prehypertension (n=1554) groups. In the univariate analysis, patient age, male sex, concurrent comorbidity (diabetes mellitus, cardiovascular disease, stroke, dyslipidemia, and chronic kidney disease), uric acid, and urinary sodium excretion were associated with prehypertension. After adjusting for baseline covariates, both the SUA level and urinary sodium excretion were significant predictors of incident prehypertension (SUA, per 1mg/dL increase, odds ratio [OR] 1.216, 95% confidence interval [95% CI] 1.131-1.309; urinary sodium excretion, per 1g/day increase, OR 1.067, 95% CI 1.019-1.117). Additionally, simultaneously higher tertiles of SUA and urinary sodium excretion resulted in higher ORs for prehypertension.ConclusionIncreased SUA is a significant risk marker for the development of prehypertension in normotensives. Simultaneously high SUA and urinary sodium excretion amplified the effect on the development of prehypertension. Our findings suggest that lowering SUA levels and reducing sodium intake will contribute to preventing hypertension.
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
- Files in This Item:
There are no files associated with this item.
- RIS (EndNote)
- XLS (Excel)
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.