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Impact of Oncotype DX Recurrence Score on the Patterns of Locoregional Recurrence in Breast Cancer (Korean Radiation Oncology Group 19-06)
- Title
- Impact of Oncotype DX Recurrence Score on the Patterns of Locoregional Recurrence in Breast Cancer (Korean Radiation Oncology Group 19-06)
- Authors
- Kim, Kyubo; Jung, Jinhong; Shin, Kyung Hwan; Kim, Jin Ho; Chang, Ji Hyun; Kim, Su Ssan; Kim, Haeyoung; Park, Won; Kim, Yong Bae; Chang, Jee Suk
- Ewha Authors
- 김규보
- SCOPUS Author ID
- 김규보
- Issue Date
- 2020
- Journal Title
- JOURNAL OF BREAST CANCER
- ISSN
- 1738-6756
2092-9900
- Citation
- JOURNAL OF BREAST CANCER vol. 23, no. 3, pp. 314 - 319
- Keywords
- Breast neoplasm; Local neoplasm recurrence; Radiotherapy
- Publisher
- KOREAN BREAST CANCER SOC
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- The current study evaluated the impact of the Oncotype DX recurrence score (RS) on the patterns of locoregional recurrence (LRR) in node-negative, hormone receptor-positive/human epidermal growth factor receptor 2-negative breast cancer. Totally, 339 patients from 4 institutions were enrolled and analyzed retrospectively. All patients underwent breast-conserving surgery followed by whole-breast irradiation; only 2 patients received regional nodal irradiation (RNI). The RS was < 11 in 55 patients, 11-25 in 241, and > 25 in 43. Sixty-two patients received adjuvant chemotherapy. All patients except 4 received hormonal therapy. During a 62-month median follow-up, local recurrence was observed in 1 patient; regional recurrence, 3; and distant metastasis, 7. All LRRs were observed among patients with a RS > 25, resulting in a 5-year LRR rate of 7.3% in this subgroup. Regional recurrences developed in patients did not receive RNI initially. Thus, RNI might be effective for patients with a high RS.
- DOI
- 10.4048/jbc.2020.23.e36
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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