Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 이상은 | - |
dc.date.accessioned | 2020-07-16T16:30:07Z | - |
dc.date.available | 2020-07-16T16:30:07Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 1941-9651 | - |
dc.identifier.issn | 1942-0080 | - |
dc.identifier.other | OAK-27222 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/254174 | - |
dc.description.abstract | Background: Preclinical studies and pilot patient studies have shown that chronic infarctions can be detected and characterized from cardiac magnetic resonance without gadolinium-based contrast agents using native-T1 maps at 3T. We aimed to investigate the diagnostic capacity of this approach for characterizing chronic myocardial infarctions (MIs) in a multi-center setting. Methods: Patients with a prior MI (n=105) were recruited at 3 different medical centers and were imaged with native-T1 mapping and late gadolinium enhancement (LGE) at 3T. Infarct location, size, and transmurality were determined from native-T1 maps and LGE. Sensitivity, specificity, receiver-operating characteristic metrics, and inter- and intraobserver variabilities were assessed relative to LGE. Results: Across all subjects, T1 of MI territory was 1621 +/- 110 ms, and remote territory was 1225 +/- 75 ms. Sensitivity, specificity, and area under curve for detecting MI location based on native-T1 mapping relative to LGE were 88%, 92%, and 0.93, respectively. Native-T1 maps were not different for measuring infarct size (native-T1 maps: 12.1 +/- 7.5%; LGE: 11.8 +/- 7.2%,P=0.82) and were in agreement with LGE (R-2=0.92, bias, 0.09 +/- 2.6%). Corresponding inter- and intraobserver assessments were also highly correlated (interobserver:R-2=0.90, bias, 0.18 +/- 2.4%; and intraobserver:R-2=0.91, bias, 0.28 +/- 2.1%). Native T1 maps were not different for measuring MI transmurality (native-T1 maps: 49.1 +/- 15.8%; LGE: 47.2 +/- 19.0%,P=0.56) and showed agreement (R-2=0.71; bias, 1.32 +/- 10.2%). Corresponding inter- and intraobserver assessments were also in agreement (interobserver:R-2=0.81, bias, 0.1 +/- 9.4%; and intraobserver:R-2=0.91, bias, 0.28 +/- 2.1%, respectively). While the overall accuracy for detecting MI with native-T1 maps at 3T was high, logistic regression analysis showed that MI location was a prominent confounder. Conclusions: Native-T1 mapping can be used to image chronic MI with high degree of accuracy, and as such, it is a viable alternative for scar imaging in patients with chronic MI who are contraindicated for LGE. Technical advancements may be needed to overcome the imaging confounders that currently limit native-T1 mapping from reaching equivalent detection levels as LGE. | - |
dc.language | English | - |
dc.publisher | LIPPINCOTT WILLIAMS & | - |
dc.publisher | WILKINS | - |
dc.subject | area under curve | - |
dc.subject | contrast media | - |
dc.subject | gadolinium | - |
dc.subject | myocardial infarction | - |
dc.subject | magnetic resonance imaging | - |
dc.title | Multicenter Study on the Diagnostic Performance of Native-T1 Cardiac Magnetic Resonance of Chronic Myocardial Infarctions at 3T | - |
dc.type | Article | - |
dc.relation.issue | 6 | - |
dc.relation.volume | 13 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.journaltitle | CIRCULATION-CARDIOVASCULAR IMAGING | - |
dc.identifier.doi | 10.1161/CIRCIMAGING.119.009894 | - |
dc.identifier.wosid | WOS:000543399900002 | - |
dc.author.google | Wang, Guan | - |
dc.author.google | Lee, Sang-Eun | - |
dc.author.google | Yang, Qi | - |
dc.author.google | Sadras, Vignesh | - |
dc.author.google | Patel, Suraj | - |
dc.author.google | Yang, Hsin-Jung | - |
dc.author.google | Sharif, Behzad | - |
dc.author.google | Kali, Avinash | - |
dc.author.google | Cokic, Ivan | - |
dc.author.google | Xie, Guoxi | - |
dc.author.google | Tighiouart, Mourad | - |
dc.author.google | Collins, Jeremy | - |
dc.author.google | Li, Debiao | - |
dc.author.google | Berman, Daniel S. | - |
dc.author.google | Chang, Hyuk-Jae | - |
dc.author.google | Dharmakumar, Rohan | - |
dc.contributor.scopusid | 이상은(57213176330) | - |
dc.date.modifydate | 20230208112553 | - |