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Oral health and gastrointestinal cancer: A nationwide cohort study

Title
Oral health and gastrointestinal cancer: A nationwide cohort study
Authors
Lee, KijeongLee, Ji SungKim, JinkwonLee, HuisongChang, YoonkyungWoo, Ho GeolKim, Jin-WooSong, Tae-Jin
Ewha Authors
송태진이희성김진우장윤경우호걸
SCOPUS Author ID
송태진scopus; 김진우scopus
Issue Date
2020
Journal Title
JOURNAL OF CLINICAL PERIODONTOLOGY
ISSN
0303-6979JCR Link

1600-051XJCR Link
Citation
JOURNAL OF CLINICAL PERIODONTOLOGY vol. 47, no. 7, pp. 796 - 808
Keywords
gastrointestinal canceroral hygieneperiodontal disease
Publisher
WILEY
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Aims Poor oral hygiene is closely associated with bacteraemia and systemic inflammation, which are known mediators of cancer development. We investigated the relationship between oral hygiene indicators and the risk of gastrointestinal cancer in a nationwide population-based cohort. Materials and Methods This study was conducted on data from 150,774 subjects from the Korean National Health Screening Cohort. The occurrence of gastrointestinal cancer was analysed according to the presence of periodontal disease and oral hygiene indicators: frequency of toothbrushing, dental visits for any reason, professional dental cleanings and number of missing teeth. Gastrointestinal cancer was defined using International Statistical Classification of Diseases-10 codes C15-C26. Results During a median 11.6 years of follow-up, the estimated 10-year event rate for gastrointestinal cancer was 6.76%. In a multivariable analysis, after adjusting for age, sex, income level, regular exercise, alcohol consumption, smoking status, body mass index, history of comorbidities, systolic blood pressure and laboratory findings, frequent toothbrushing (>= 3/day) was significantly associated with a reduced risk for gastrointestinal cancer (hazard ratio: 0.91, 95% confidence interval (0.86-0.96), p < .001, p for trend < .001). Conclusions Good oral hygiene behaviour, especially frequent toothbrushing, could be associated with a lower risk of gastrointestinal cancer.
DOI
10.1111/jcpe.13304
Appears in Collections:
의과대학 > 의학과 > Journal papers
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