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Clinical impact of pre-hypertension on the risk of cancer in male and female subjects

Title
Clinical impact of pre-hypertension on the risk of cancer in male and female subjects
Authors
Lee S.H.Lee H.A.Lee S.S.Kim S.-E.Shim K.-N.Jung H.-K.Jung S.-A.Chang J.H.Kwon K.Pyun W.B.Joung B.Moon C.M.Park J.
Ewha Authors
장중현정성애정혜경심기남권기환편욱범김성은문창모박준범이혜아
SCOPUS Author ID
장중현scopus; 정성애scopus; 정혜경scopus; 심기남scopus; 권기환scopus; 편욱범scopus; 김성은scopus; 문창모scopus; 박준범scopus; 이혜아scopus
Issue Date
2020
Journal Title
Scientific Reports
ISSN
2045-2322JCR Link
Citation
Scientific Reports vol. 10, no. 1
Publisher
Nature Research
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
There are few studies assessing pre-hypertension and an impaired fasting glucose (IFG) and their combined effects on the cancer risk. We investigated the impact of pre-hypertension on cancer risk and IFG, and their combined effects on the cancer risk. This study included 371,762 subjects (≥40 years) who had never been diagnosed with hypertension, diabetes mellitus (DM), and cancer before. During a mean follow-up of 10.06 ± 1.86 years, 35,605 (9.58%) of the subjects developed cancer. In men only, cancer risk was significantly increased with an increase in the blood pressure (BP) (P for trend < 0.001), and were increased in the hypertension range, but not the pre-hypertension range. When analyzing the combination effect of BP and fasting glucose, cancer risks were serially increased with an increase in the fasting glucose in a dose-dependent manner, but not with an increase in BP. These results were more consistently significant in the never-smoker and non-alcohol drinking groups. However, in women, there was no significant difference. In conclusions, increased BP status or the fasting serum glucose level status were associated with cancer risk in men. Furthermore, the combination of both pre-hypertension and IFG also was associated with a cancer risk in men. © 2020, The Author(s).
DOI
10.1038/s41598-020-66653-y
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의과대학 > 의학과 > Journal papers
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