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The Autophagy Regulator p62 Controls PTEN-Dependent Ciliogenesis

Title
The Autophagy Regulator p62 Controls PTEN-Dependent Ciliogenesis
Authors
Mun, HyowonLee, Eun JiPark, MinahOh, Goo TaegPark, Jong Hoon
Ewha Authors
오구택
SCOPUS Author ID
오구택scopus
Issue Date
2020
Journal Title
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
ISSN
2296-634XJCR Link
Citation
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY vol. 8
Keywords
autophagyciliaciliogenesisSQSTM1p62PTEN
Publisher
FRONTIERS MEDIA SA
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Autophagy is a catabolic process required for maintaining intracellular energy homeostasis. It eliminates harmful proteins and recycles functional macromolecules back into the cell via cargo breakdown. Autophagy is generally suppressed under fed conditions and induced by serum starvation; therefore, it is considered to be a nutrient-sensing mechanism. Cilia, finger-like organelles harboring multiple receptors along their surface, are energy-sensing structures that are also triggered by serum deprivation. Herein, we verified the effect of autophagy alterations on cilia assembly and the specific underlying mechanisms. Autophagy flux altered either by drugs or autophagy-targeting siRNAs strongly inhibited ciliogenesis, and this inhibition was affected by p62, an autophagy regulator, via Pten/Dvl2/AurKA signaling.
DOI
10.3389/fcell.2020.00465
Appears in Collections:
자연과학대학 > 생명과학전공 > Journal papers
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