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dc.contributor.author정지향-
dc.contributor.author박희경-
dc.date.accessioned2020-06-08T16:30:16Z-
dc.date.available2020-06-08T16:30:16Z-
dc.date.issued2020-
dc.identifier.issn1738-6586-
dc.identifier.issn2005-5013-
dc.identifier.otherOAK-26975-
dc.identifier.urihttp://dspace.ewha.ac.kr/handle/2015.oak/254045-
dc.description.abstractBackground and Purpose The prevalence of dementia is increasing in South Korea. Multidomain interventions may be useful for preventing dementia. Such programs need to be disseminated to elderly Koreans throughout the country. We have developed programs of the SoUth Korean study to PrEvent cognitive impaiRment and protect BRAIN health through lifestyle intervention in at-risk elderly people (SUPERBRAIN), which consists of a facility-based multidomain intervention (FMI) program and a home-based multidomain intervention (HMI) program suitable for elderly Koreans. We aim to determine the feasibility of the SUPERBRAIN programs before a large-scale randomized controlled trial. Methods We will recruit 150 participants among those without dementia aged 60-79 years with at least 1 modifiable dementia risk factor. They will be randomly assigned in a 1:1:1 ratio to the FMI, HMI, and the waiting-list control arm. The 6-month multidomain intervention consists of management of metabolic and vascular risk factors, cognitive training and social activity, physical exercise, nutritional guidance, and motivational enhancement programs. The primary outcomes are adherence and retention rates and changes in the total scale index score of the Repeatable Battery for the Assessment of Neuropsychological Status from baseline to the study end. The main secondary outcomes are disability, depressive symptoms, quality of life, vascular risk factors, physical performance, nutritional assessment, and motivation questionnaire. There will be an exploratory evaluation of neurotrophic, neurodegeneration, and neuroinflammation factors, microbiome, telomere length, electroencephalography, and neuroimaging measures. Conclusions The results obtained will provide information on the applicability of these multi domain intervention programs to at-risk elderly people.-
dc.languageEnglish-
dc.publisherKOREAN NEUROLOGICAL ASSOC-
dc.subjectcognitive impairment-
dc.subjectdementia-
dc.subjectlifestyle-
dc.subjectprevention-
dc.subjectrandomized controlled trial-
dc.titleSouth Korean Study to Prevent Cognitive Impairment and Protect Brain Health Through Lifestyle Intervention in At-Risk Elderly People: Protocol of a Multicenter, Randomized Controlled Feasibility Trial-
dc.typeArticle-
dc.relation.issue2-
dc.relation.volume16-
dc.relation.indexSCIE-
dc.relation.indexSCOPUS-
dc.relation.indexKCI-
dc.relation.startpage292-
dc.relation.lastpage303-
dc.relation.journaltitleJOURNAL OF CLINICAL NEUROLOGY-
dc.identifier.doi10.3988/jcn.2020.16.2.292-
dc.identifier.wosidWOS:000527858700014-
dc.author.googlePark, Hee Kyung-
dc.author.googleJeong, Jee Hyang-
dc.author.googleMoon, So Young-
dc.author.googlePark, Yoo Kyoung-
dc.author.googleHong, Chang Hyung-
dc.author.googleNa, Hae Ri-
dc.author.googleSong, Hong-Sun-
dc.author.googleLee, Sun Min-
dc.author.googleChoi, Muncheong-
dc.author.googlePark, Kyung Won-
dc.author.googleKim, Byeong C.-
dc.author.googleCho, Soo Hyun-
dc.author.googleChun, Buong-O-
dc.author.googleChoi, Seong Hye-
dc.contributor.scopusid정지향(7402045750)-
dc.date.modifydate20200608135925-
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의과대학 > 의학과 > Journal papers
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