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Two new secondary metabolites, saccharochlorines A and B, from a marine bacterium Saccharomonospora sp. KCTC-19160
- Two new secondary metabolites, saccharochlorines A and B, from a marine bacterium Saccharomonospora sp. KCTC-19160
- Le, Tu Cam; Katila, Nikita; Park, Songhee; Lee, Jihye; Yang, Inho; Choi, Hyukjae; Choi, Dong-Young; Nam, Sang-Jip
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS vol. 30, no. 11
- Saccharomonospora sp.; Marine natural products; Chlorinated secondary metabolites
- PERGAMON-ELSEVIER SCIENCE LTD
- SCIE; SCOPUS
- Document Type
- Two new chlorinated secondary metabolites, saccharochlorines A and B (1 and 2), were isolated from the saline cultivation of a marine-derived bacterium Saccharomonospora sp. (KCTC-19160). The chemical structures of the saccharochlorines were elucidated by 2D NMR and MS spectroscopic data. Saccharochlorines A and B (1 and 2) exhibit weak inhibition of beta-secretase (BACE1) in biochemical inhibitory assay, but they induced the release of A beta (1-40) and A beta (1-42) in H4-APP neuroglial cells. This discrepancy might be derived from the differences between the cellular and sub-cellular environments or the epigenetic stimulation of BACE1 expression.
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