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Two new secondary metabolites, saccharochlorines A and B, from a marine bacterium Saccharomonospora sp. KCTC-19160

Title
Two new secondary metabolites, saccharochlorines A and B, from a marine bacterium Saccharomonospora sp. KCTC-19160
Authors
Le, Tu CamKatila, NikitaPark, SongheeLee, JihyeYang, InhoChoi, HyukjaeChoi, Dong-YoungNam, Sang-Jip
Ewha Authors
남상집
SCOPUS Author ID
남상집scopus
Issue Date
2020
Journal Title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN
0960-894XJCR Link

1464-3405JCR Link
Citation
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS vol. 30, no. 11
Keywords
Saccharomonospora sp.Marine natural productsChlorinated secondary metabolites
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Two new chlorinated secondary metabolites, saccharochlorines A and B (1 and 2), were isolated from the saline cultivation of a marine-derived bacterium Saccharomonospora sp. (KCTC-19160). The chemical structures of the saccharochlorines were elucidated by 2D NMR and MS spectroscopic data. Saccharochlorines A and B (1 and 2) exhibit weak inhibition of beta-secretase (BACE1) in biochemical inhibitory assay, but they induced the release of A beta (1-40) and A beta (1-42) in H4-APP neuroglial cells. This discrepancy might be derived from the differences between the cellular and sub-cellular environments or the epigenetic stimulation of BACE1 expression.
DOI
10.1016/j.bmcl.2020.127145
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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