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Whole-Cell Photoenzymatic Cascades to Synthesize Long-Chain Aliphatic Amines and Esters from Renewable Fatty Acids
- Title
- Whole-Cell Photoenzymatic Cascades to Synthesize Long-Chain Aliphatic Amines and Esters from Renewable Fatty Acids
- Authors
- Cha H.-J.; Hwang S.-Y.; Lee D.-S.; Kumar A.R.; Kwon Y.-U.; Voß M.; Schuiten E.; Bornscheuer U.T.; Hollmann F.; Oh D.-K.; Park J.-B.
- Ewha Authors
- 박진병; 권용억
- SCOPUS Author ID
- 박진병; 권용억
- Issue Date
- 2020
- Journal Title
- Angewandte Chemie - International Edition
- ISSN
- 1433-7851
- Citation
- Angewandte Chemie - International Edition vol. 59, no. 18, pp. 7024 - 7028
- Keywords
- Biocatalysis; fatty acids; long-chain aliphatic amines; photodecarboxylase; whole-cell biocatalysis
- Publisher
- Wiley-VCH Verlag
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Long-chain aliphatic amines such as (S,Z)-heptadec-9-en-7-amine and 9-aminoheptadecane were synthesized from ricinoleic acid and oleic acid, respectively, by whole-cell cascade reactions using the combination of an alcohol dehydrogenase (ADH) from Micrococcus luteus, an engineered amine transaminase from Vibrio fluvialis (Vf-ATA), and a photoactivated decarboxylase from Chlorella variabilis NC64A (Cv-FAP) in a one-pot process. In addition, long chain aliphatic esters such as 10-(heptanoyloxy)dec-8-ene and octylnonanoate were prepared from ricinoleic acid and oleic acid, respectively, by using the combination of the ADH, a Baeyer–Villiger monooxygenase variant from Pseudomonas putida KT2440, and the Cv-FAP. The target compounds were produced at rates of up to 37 U g−1 dry cells with conversions up to 90 %. Therefore, this study contributes to the preparation of industrially relevant long-chain aliphatic chiral amines and esters from renewable fatty acid resources. © 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
- DOI
- 10.1002/anie.201915108
- Appears in Collections:
- 공과대학 > 식품생명공학과 > Journal papers
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