View : 140 Download: 0

Emerging risk of environmental factors: insight mechanisms of Alzheimer's diseases

Title
Emerging risk of environmental factors: insight mechanisms of Alzheimer's diseases
Authors
Rahman, Md AtaurRahman, Md SaidurUddin, Md JamalMamum-Or-Rashid, A. N. M.Pang, Myung-GeolRhim, Hyewhon
Ewha Authors
Md Jamal Uddin
Journal Title
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
ISSN
0944-1344JCR Link

1614-7499JCR Link
Citation
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
Keywords
Alzheimer's diseasesEnvironmental factorsAmyloid betaTau phosphorylation
Publisher
SPRINGER HEIDELBERG
Indexed
SCIE; SCOPUS WOS
Document Type
Article

Early Access
Abstract
Neurodegenerative disorders are typically sporadic in nature in addition to usually influenced through an extensive range of environmental factors, lifestyle, and genetic elements. Latest observations have hypothesized that exposure of environmental factors may increase the prospective risk of Alzheimer's diseases (AD). However, the role of environmental factors as a possible dangerous issue has extended importance concerned in AD pathology, although actual etiology of the disorder is still not yet clear. Thus, the aim of this review is to highlight the possible correlation between environmental factors and AD, based on the present literature view. Environmental risk factors might play an important role in decelerating or accelerating AD progression. Among well-known environmental risk factors, prolonged exposure to several heavy metals, for example, aluminum, arsenic, cadmium, lead, and mercury; particulate air, and some pesticides as well as metal-containing nanoparticles have been participated to cause AD. These heavy metals have the capacity to enhance amyloid beta (A beta) peptide along with tau phosphorylation, initiating amyloid/senile plaques, as well as neurofibrillary tangle formation; therefore, neuronal cell death has been observed. Furthermore, particulate air, pesticides, and heavy metal exposure have been recommended to lead AD susceptibility and phenotypic diversity though epigenetic mechanisms. Therefore, this review deliberates recent findings detailing the mechanisms for a better understanding the relationship between AD and environmental risk factors along with their mechanisms of action on the brain functions.
DOI
10.1007/s11356-020-08243-z
Appears in Collections:
연구기관 > 약학연구소 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE