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Tumor-derived exosomal miR-619-5p promotes tumor angiogenesis and metastasis through the inhibition of RCAN1.4

Title
Tumor-derived exosomal miR-619-5p promotes tumor angiogenesis and metastasis through the inhibition of RCAN1.4
Authors
Kim, Dong HaPark, SojungKim, HyeongRyulChoi, Yun JungKim, Seon YeSung, Ki JungSung, Young HoonChoi, Chang-MinYun, MiyongYi, Young-SuLee, Chae WonKim, Sang-YeobLee, Jae CheolRho, Jin Kyung
Ewha Authors
박소정
Issue Date
2020
Journal Title
CANCER LETTERS
ISSN
0304-3835JCR Link

1872-7980JCR Link
Citation
CANCER LETTERS vol. 475, pp. 2 - 13
Keywords
Non-small cell lung cancerExosomal miRNAsRCAN1ExosomeTumor growth
Publisher
ELSEVIER IRELAND LTD
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Tumor derived exosomes (TEXs) contain enriched miRNAs that act as novel non-invasive biomarkers for cancer diagnosis and play a role in cancer progression. We investigated the exosomal miRNAs that affect cancer progression in non-small cell lung cancer (NSCLC) and identified the specific molecules involved. We identified that specific miRNAs in NSCLC cell-released exosomes can modulate angiogenesis, among which miR-619-5p was the most potent inducer. RCAN1.4 was identified as a target of miR-619-5p and its suppression promoted angiogenesis. Furthermore, the suppression of RCAN1.4 induced cell proliferation and metastasis in NSCLC cells. In patients with NSCLC, the level of RCAN1.4 expression was significantly lower, and that of miR-619.5p significantly higher, in tumor than normal lung tissues. miR-619-5p expression was higher than normal in exosomes isolated from the plasma of NSCLC patients. Finally, hypoxic conditions induced miR-619-5p upload into NSCLC cell-derived exosomes. Our findings indicate that exosomal miR-619-5p promotes the growth and metastasis of NSCLCs by regulating RCAN1.4 and can serve as a diagnostic indicator for these lung cancers.
DOI
10.1016/j.canlet.2020.01.023
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의료원 > 의료원 > Journal papers
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