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A lysosome-localized thionaphthalimide as a potential heavy-atom-free photosensitizer for selective photodynamic therapy

Title
A lysosome-localized thionaphthalimide as a potential heavy-atom-free photosensitizer for selective photodynamic therapy
Authors
Nguyen V.-N.Baek G.Qi S.Heo S.Yim Y.Yoon J.
Ewha Authors
윤주영
SCOPUS Author ID
윤주영scopus
Issue Date
2020
Journal Title
Dyes and Pigments
ISSN
0143-7208JCR Link
Citation
Dyes and Pigments vol. 177
Keywords
Heavy-atom-free photosensitizerIntersystem crossingPhotodynamic therapyReactive oxygen speciesSulfur-substituted naphthalimide
Publisher
Elsevier Ltd
Indexed
SCI; SCIE; SCOPUS scopus
Document Type
Article
Abstract
A novel sulfur-substituted naphthalimide (LSNI-S) was synthesized and investigated as a promising lysosome-targeting photosensitizer for photodynamic cancer therapy. The introduction of a dual-functional morpholine group to the 4-position of the naphthalimide backbone combined with the substitution of oxygen atoms by sulfur atoms could facilitate intersystem crossing from the excited singlet state to the reactive triplet state, leading to an excellent singlet oxygen generation efficiency of LSNI-S in organic solvents (ΦΔ ≈ 0.84 in air-saturated acetonitrile). Interestingly, LSNI-S could produce reactive oxygen species via both type-I and type-II mechanisms under physiological conditions. In particular, cell studies demonstrated that LSNI-S selectively localizes in lysosomes of cancer cells and exhibits excellent photodynamic therapy efficacy. © 2020 Elsevier Ltd
DOI
10.1016/j.dyepig.2020.108265
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자연과학대학 > 화학·나노과학전공 > Journal papers
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