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FKBP5-associated miRNA signature as a putative biomarker for PTSD in recently traumatized individuals

Title
FKBP5-associated miRNA signature as a putative biomarker for PTSD in recently traumatized individuals
Authors
Kang H.J.Yoon S.Lee S.Choi K.Seol S.Park S.Namgung E.Kim T.D.Chung Y.-A.Kim J.Han J.-S.Lyoo I.K.
Ewha Authors
류인균윤수정김정윤
SCOPUS Author ID
류인균scopus; 윤수정scopus; 김정윤scopus
Issue Date
2020
Journal Title
Scientific reports
ISSN
2045-2322JCR Link
Citation
Scientific reports vol. 10, no. 1, pp. 3353
Publisher
NLM (Medline)
Indexed
SCI; SCIE; SCOPUS scopus
Document Type
Article
Abstract
The epigenetic regulation of microRNA (miRNA) expression related to the FK506-binding protein 5 (FKBP5) gene may contribute to the risk of stress-related disorders such as posttraumatic stress disorder (PTSD). Here, we identified candidate miRNAs derived from FKBP5 knockout mice as a potential diagnostic biomarker of PTSD. Using a translational approach, candidate miRNAs found to alter in expression within the medial prefrontal cortex of FKBP5 knockout mice were selected. Each candidate miRNA was examined in the serum of 48 recently traumatized individuals with PTSD and 47 healthy individuals. Multimodal imaging was also conducted to identify the neural correlates for the expression of candidate exosomal miRNAs in response to trauma exposure. Differential miRNA expression was found according to PTSD diagnosis in two composite marker groups. The differential miRNA expression between the composite marker groups contributed to PTSD symptom severity, which may be explained by differential recruitment of prefrontolimbic activity in brain imaging. The present study reveals that a set of circulating exosomal miRNAs showing altered expression in FKBP5 knockout mice play a potential role as epigenetic markers of PTSD. The corroborative evidence from multiple levels including molecular, brain, and behavioral indicates that these epigenetic biomarkers may serve as complementary measures for the diagnosis and prognosis prediction of PTSD in recently traumatized individuals.
DOI
10.1038/s41598-020-60334-6
Appears in Collections:
약학대학 > 약학과 > Journal papers
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