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Pulmonary alveolar proteinosis in Korea: analysis of prevalence and incidence via a nationwide population-based study

Title
Pulmonary alveolar proteinosis in Korea: analysis of prevalence and incidence via a nationwide population-based study
Authors
Yoon, Hee-youngKim, Ji HyeonKim, Ye-JeeSong, Jin Woo
Ewha Authors
윤희영
Issue Date
2020
Journal Title
BMC PULMONARY MEDICINE
ISSN
1471-2466JCR Link
Citation
BMC PULMONARY MEDICINE vol. 20, no. 1
Keywords
EpidemiologyInsurance claim reviewHealth care surveyNational Health ProgramsRare diseases
Publisher
BMC
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Background Pulmonary alveolar proteinosis (PAP) is a very rare lung disease and its prevalence and incidence remain unclear. The prevalence and incidence of PAP were investigated by using nationwide claims data from the Korean Health Insurance Review and Assessment service. Methods Data were extracted for adults who visited any secondary or tertiary medical institute between 2010 and 2016 with the PAP-related Korean Classification of Disease, 7th edition code J84.0 and the Rare Intractable Disease exempted calculation code V222. To robust case definition, a narrow case definition was made when all following factors were met: 1) more than two PAP-coded visits within 1 year of the first claim, and 2) more than one claim for both chest computed tomography and diagnostic procedures (bronchoscopy or surgical lung biopsy) within 90 days before or after the first claim. Results A total of 182 patients (narrow, n = 82) with PAP-related codes were identified from 2010 to 2016 and 89 new patients (narrow, n = 66) visited medical institutes between 2012 and 2015. The prevalence of PAP was 4.44 (narrow: 2.27) per 10(6) population, with a peak age of 60-69 years. The incidence of PAP was 0.56 (narrow: 0.41) per 10(6) population at risk, with a peak age of 50-59 years. Among incident cases, the male-to-female ratio was 1.52 and about two-thirds had comorbidities, dyslipidaemia being the most common. Conclusions The prevalence and incidence of PAP in Korea are low, similar to those in other countries; however, Korean patients with PAP are characterized by older diagnostic age and a lower male-to-female ratio.
DOI
10.1186/s12890-020-1074-5
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의료원 > 의료원 > Journal papers
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