Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 홍영미 | * |
dc.contributor.author | 손세정 | * |
dc.date.accessioned | 2020-02-07T16:30:14Z | - |
dc.date.available | 2020-02-07T16:30:14Z | - |
dc.date.issued | 2020 | * |
dc.identifier.issn | 1470-269X | * |
dc.identifier.issn | 1473-1150 | * |
dc.identifier.other | OAK-26394 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/253348 | - |
dc.description.abstract | Kawasaki disease (KD) is a systemic vasculitis affecting infants and children; it manifests as fever and signs of mucocutaneous inflammation. Intravenous immunoglobulin (IVIG) treatment effectively attenuates the fever and systemic inflammation. However, 10-20% patients are unresponsive to IVIG. To identify genetic variants influencing IVIG non-response in KD, a genome-wide association study (GWAS) and a replication study were performed using a total of 148 IVIG non-responders and 845 IVIG-responders in a Korean population. rs28662 in the sterile alpha motif domain-containing protein 9-like (SAMD9L) locus showed the most significant result in the joint analysis of GWAS and replication samples (odds ratio (OR) = 3.47, P = 1.39 x 10(-5)). The same SNP in the SAMD9L locus was tested in the Japanese population, and it revealed a more significant association in a meta-analysis with Japanese data (OR = 4.30, P = 5.30 x 10(-6)). These results provide new insights into the mechanism of IVIG response in KD. | * |
dc.language | English | * |
dc.publisher | NATURE PUBLISHING GROUP | * |
dc.title | Identification of SAMD9L as a susceptibility locus for intravenous immunoglobulin resistance in Kawasaki disease by genome-wide association analysis | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 20 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 80 | * |
dc.relation.lastpage | 86 | * |
dc.relation.journaltitle | PHARMACOGENOMICS JOURNAL | * |
dc.identifier.doi | 10.1038/s41397-019-0085-1 | * |
dc.identifier.wosid | WOS:000510861200007 | * |
dc.identifier.scopusid | 2-s2.0-85064201489 | * |
dc.author.google | Kim, Jae-Jung | * |
dc.author.google | Yun, Sin Weon | * |
dc.author.google | Yu, Jeong Jin | * |
dc.author.google | Yoon, Kyung Lim | * |
dc.author.google | Lee, Kyung-Yil | * |
dc.author.google | Kil, Hong-Ryang | * |
dc.author.google | Kim, Gi Beom | * |
dc.author.google | Han, Myung-Ki | * |
dc.author.google | Song, Min Seob | * |
dc.author.google | Lee, Hyoung Doo | * |
dc.author.google | Ha, Kee Soo | * |
dc.author.google | Sohn, Sejung | * |
dc.author.google | Ebata, Ryota | * |
dc.author.google | Hamada, Hiromichi | * |
dc.author.google | Suzuki, Hiroyuki | * |
dc.author.google | Ito, Kaoru | * |
dc.author.google | Onouchi, Yoshihiro | * |
dc.author.google | Hong, Young Mi | * |
dc.author.google | Jang, Gi Young | * |
dc.author.google | Lee, Jong-Keuk | * |
dc.author.google | Park, In-Sook | * |
dc.author.google | Hong, Soo-Jong | * |
dc.author.google | Kim, Kwi-Joo | * |
dc.author.google | Nam, Hyo-Kyoung | * |
dc.author.google | Byeon, Jung-Hye | * |
dc.author.google | Hwang, Ja-Young | * |
dc.author.google | Rhim, Jung-Woo | * |
dc.author.google | Kim, Dong Soo | * |
dc.author.google | Lee, Jae-Moo | * |
dc.author.google | Kim, Jong-Duk|Korean Kawasaki Dis Genetics Conso | * |
dc.contributor.scopusid | 홍영미(35210025100;55841904000;56063366100) | * |
dc.contributor.scopusid | 손세정(56577409300) | * |
dc.date.modifydate | 20240415130647 | * |