Full metadata record
DC Field | Value | Language |
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dc.contributor.author | 정혜경 | - |
dc.date.accessioned | 2020-02-07T16:30:10Z | - |
dc.date.available | 2020-02-07T16:30:10Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 1976-2283 | - |
dc.identifier.issn | 2005-1212 | - |
dc.identifier.other | OAK-26419 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/253326 | - |
dc.description.abstract | Background/AIms: Although acid suppressants are widely used for the prevention or treatment of drug-induced upper gastrointestinal bleeding (GIB), evidence regarding the prevention of anticoagulant-related GIB is scarce. The aim of this study was to evaluate the protective effect of acid suppressants against anticoagulant-related GIB. Methods: A systematic review was conducted of studies that evaluated the protective effect of acid suppressants against anticoagulant-related GIB found in PubMed, the Cochrane library, Embase, and KoreaMed from the date of database inception to April 2018. Random effect model meta-analyses with sensitivity analyses were conducted. The methodological quality of each included publication was evaluated using the Risk of Bias Assessment Tool for Nonrandomized Studies. Publication bias was assessed. Results: In total, six nested case-control or cohort studies were identified and analyzed. Proton-pump inhibitors (PPI) had a protective effect against upper GIB in patients on dicumarinics (risk ratio [RR], 0.56; 95% confidence interval [CI], 0.38 to 0.83; I-2, 0%); however, the histamine-2 receptor antagonist did not have the same effect (RR, 0.97; 95% CI, 0.52 to 1.81; I-2, 0%). Acid suppressants did not have a protective effect against GIB in patients on dabigatran (hazard ratio, 0.78; 95% CI, 0.44 to 1.37; I-2, 81.8%). Conclusions: The protective effect of PPIs against dicumarinics-related upper GIB was clear, while there was no evidence supporting the protective effect of acid suppressants against dabigatran-related GIB. However, in the absence of randomized trials demonstrating a lack of bias, solid conclusions cannot be drawn. | - |
dc.language | English | - |
dc.publisher | EDITORIAL OFFICE GUT & | - |
dc.publisher | LIVER | - |
dc.subject | Anticoagulants | - |
dc.subject | Acid suppressants | - |
dc.subject | Gastrointestinal hemorrhage | - |
dc.title | The Role of Acid Suppressants in the Prevention of Anticoagulant-Related Gastrointestinal Bleeding: A Systematic Review and Meta-Analysis | - |
dc.type | Review | - |
dc.relation.issue | 1 | - |
dc.relation.volume | 14 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.index | KCI | - |
dc.relation.startpage | 57 | - |
dc.relation.lastpage | 66 | - |
dc.relation.journaltitle | GUT AND LIVER | - |
dc.identifier.doi | 10.5009/gnl19009 | - |
dc.identifier.wosid | WOS:000507928400009 | - |
dc.identifier.scopusid | 2-s2.0-85077943681 | - |
dc.author.google | Bang, Chang Seok | - |
dc.author.google | Joo, Moon Kyung | - |
dc.author.google | Kim, Byung-Wook | - |
dc.author.google | Kim, Joon Sung | - |
dc.author.google | Park, Chan Hyuk | - |
dc.author.google | Ahn, Ji Yong | - |
dc.author.google | Lee, Jeong Hoon | - |
dc.author.google | Lee, Bong Eun | - |
dc.author.google | Yang, Hyo-Joon | - |
dc.author.google | Cho, Yu Kyung | - |
dc.author.google | Park, Jae Myung | - |
dc.author.google | Kim, Beom Jin | - |
dc.author.google | Jung, Hye-Kyung|Korean Coll Helicobacter Upper Gas | - |
dc.contributor.scopusid | 정혜경(7403029723) | - |
dc.date.modifydate | 20230208112902 | - |