Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이혜아 | * |
dc.date.accessioned | 2020-02-07T16:30:08Z | - |
dc.date.available | 2020-02-07T16:30:08Z | - |
dc.date.issued | 2020 | * |
dc.identifier.issn | 2045-2322 | * |
dc.identifier.other | OAK-26429 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/253317 | - |
dc.description.abstract | Considering the strong correlation between carbohydrate and fat intake, we defined and assessed the association of the carbohydrate-to-fat ratio with the high-density lipoprotein cholesterol (HDL-c) level using 12-year follow-up data from the community-based cohort of the Korean Genome Epidemiology Study. We evaluated the long-term changes in HDL-c levels according to quartiles of carbohydrate-to-fat ratio using a mixed model. We also assessed the effect of the carbohydrate-to-fat ratio on the prevalence and incidence of hypo-HDL-cholesterolemia. Of 6,627 subjects, the prevalence of undiagnosed hypo-HDL-cholesterolemia at baseline was 35.3% (n = 2,339). Among the disease-free subjects, 56.8% developed hypo-HDL-cholesterolemia (incidence = 92/1,000 person-years). The prevalence and incidence of hypo-HDL-cholesterolemia were higher in females than in males. The highest carbohydrate-to-fat ratio quartile, which was characterized by high and low intake of carbohydrate and fat, was consistently associated with a lower HDL-c level during the 12-year follow up. Moreover, those in the highest quartile had a 1.14-fold greater risk of incident hypo-HDL-cholesterolemia than those in the lowest quartile, with a significant dose-response relationship. We found that high and low intake of carbohydrate and fat, respectively, was consistently associated with a low HDL-c level over a prolonged period. More research is needed to promote appropriate intake of macronutrients. © 2020, The Author(s). | * |
dc.language | English | * |
dc.publisher | Nature Research | * |
dc.title | The Effect of High Carbohydrate-to-fat Intake Ratios on Hypo-HDL-cholesterolemia Risk and HDL-cholesterol Levels over a 12-year Follow-up | * |
dc.type | Article | * |
dc.relation.issue | 1 | * |
dc.relation.volume | 10 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.journaltitle | Scientific Reports | * |
dc.identifier.doi | 10.1038/s41598-020-57931-w | * |
dc.identifier.wosid | WOS:000559820700007 | * |
dc.identifier.scopusid | 2-s2.0-85078214445 | * |
dc.author.google | Lee H.A. | * |
dc.author.google | An H. | * |
dc.contributor.scopusid | 이혜아(57188947704) | * |
dc.date.modifydate | 20240318141604 | * |