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Physiologic intestinal F-18-FDG uptake is associated with alteration of gut microbiota and proinflammatory cytokine levels in breast cancer

Title
Physiologic intestinal F-18-FDG uptake is associated with alteration of gut microbiota and proinflammatory cytokine levels in breast cancer
Authors
Yoon, Hai-JeonKim, Han-NaBang, Ji-InLim, WoosungMoon, Byung InPaik, Nam SunKim, Bom SahnKim, Hyung-Lae
Ewha Authors
김형래문병인김범산임우성백남선김한나윤혜전방지인
SCOPUS Author ID
김형래scopus; 문병인scopus; 김범산scopus; 임우성scopus; 백남선scopus; 김한나scopus; 윤혜전scopus
Issue Date
2019
Journal Title
SCIENTIFIC REPORTS
ISSN
2045-2322JCR Link
Citation
SCIENTIFIC REPORTS vol. 9
Publisher
NATURE PUBLISHING GROUP
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
The clinical significance of physiologic Fluorine-18-fluorodeoxyglucose (F-18-FDG) intestinal uptake (IU) based on the predicted link with gut microbiota dysbiosis and inflammatory cytokine production was investigated in a cohort of breast cancer patients. A total of 114 patients were visually classified into the lower or higher IU group. The maximum and mean standardized uptake values of total bowel (TB SUVmax and TB SUVmean) were measured. The gut microbial abundance of the Citrobacter genus of the Enterobacteriaceae family showed a significant positive correlation with TB SUVmax and TB SUVmean (q= 0.021 and q= 0.010). The unclassified Ruminococcaceae showed a significant negative correlation with TB SUVmax (q = 0.010). The level of tumor necrosis factor alpha (TNF-alpha) was significantly increased in the high IU group (p = 0.017). The TNF-alpha levels showed a significant positive correlation with TB SUVmax (rho = 0.220 and p= 0.018) and TB SUVmean (rho = 0.250 and p = 0.007). Therefore, our findings suggest that the physiologic intestinal uptake may reflect subclinical inflammation and differences in the composition of the gut microbiome in breast cancer patients.
DOI
10.1038/s41598-019-54680-3
Appears in Collections:
의과대학 > 의학과 > Journal papers
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