View : 95 Download: 0

Controlling inter-sheet-distance in reduced graphene oxide electrodes for highly sensitive electrochemical impedimetric sensing of myoglobin

Title
Controlling inter-sheet-distance in reduced graphene oxide electrodes for highly sensitive electrochemical impedimetric sensing of myoglobin
Authors
Yoo, Seong SooKim, So YoungKim, Kwang SuHong, SunghwanOh, Min JunNam, Myeong GyunKim, Woo-JaePark, JuhyunChung, Chan-HwaChoe, Woo-SeokYoo, Pil J.
Ewha Authors
김우재
Issue Date
2020
Journal Title
SENSORS AND ACTUATORS B-CHEMICAL
ISSN
0925-4005JCR Link
Citation
SENSORS AND ACTUATORS B-CHEMICAL vol. 305
Keywords
MyoglobinInter-sheet distanceGraphene oxideElectrochemical impedance spectroscopyBiosensors
Publisher
ELSEVIER SCIENCE SA
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
In order to improve the sensitivity of electrochemical impedance spectroscopy (EIS)-based biosensors, a number of structuring strategies to promote enlarging the electroactive surface area have been recently proposed. However, these approaches have not been applicable to graphene-based electrodes especially due to their ultrathin film thickness (usually< 10 nm) and incompatibility with top-down based structuring methods. To challenge this limitation, in this work, we presented a novel means to increase the electroactive surface area and the sensitivity of graphene electrode-based EIS biosensors with obviation of any extrinsic structuring method, such as patterning or pore generation. Instead, graphene oxide (GO) nanosheets functionalized with octadecylamine (ODA) groups to alter the inter-sheet spacing were synthesized and assembled to stacked films. Then, GO films were thermally reduced to form the roughened surface to maximize the electroactive surface area and sensing sensitivity. As a proof of concept demonstration, the sensing performances of rGO electrodes with differential inter-sheet distance were assessed via EIS measurements for the detection of myoglobin (Mb), a representative biomarker of acute myocardial infarction. Taken together, the deliberate control of the extent of interlayer alkylation of stacked GO nanosheets proved to be an effective strategy to produce rGO electrodes with significantly enhanced and/or controlled surface area, giving rise to a remarkably high sensing performance with the detection limit of 2.37 pM concentration of Mb. The presented strategy is simple yet powerful and widely applicable to various types of target molecules, it is therefore expected to provide general platform for biomedical and environmental sensors.
DOI
10.1016/j.snb.2019.127477
Appears in Collections:
엘텍공과대학 > 화학신소재공학전공 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE