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Deubiquitinating Enzymes: A Critical Regulator of Mitosis

Title
Deubiquitinating Enzymes: A Critical Regulator of Mitosis
Authors
Park, JinyoungCho, JinhongKim, Eunice EunKyeongSong, Eun Joo
Ewha Authors
송은주
Issue Date
2019
Journal Title
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
ISSN
1422-0067JCR Link
Citation
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES vol. 20, no. 23
Keywords
mitosisubiquitinationdeubiquitinationcancer
Publisher
MDPI
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Review
Abstract
Mitosis is a complex and dynamic process that is tightly regulated by a large number of mitotic proteins. Dysregulation of these proteins can generate daughter cells that exhibit genomic instability and aneuploidy, and such cells can transform into tumorigenic cells. Thus, it is important for faithful mitotic progression to regulate mitotic proteins at specific locations in the cells at a given time in each phase of mitosis. Ubiquitin-dependent modifications play critical roles in this process by regulating the degradation, translocation, or signal transduction of mitotic proteins. Here, we review how ubiquitination and deubiquitination regulate the progression of mitosis. In addition, we summarize the substrates and roles of some deubiquitinating enzymes (DUBs) crucial for mitosis and describe how they contribute error correction during mitosis and control the transition between the mitotic phases.
DOI
10.3390/ijms20235997
Appears in Collections:
약학대학 > 약학과 > Journal papers
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