Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 한평림 | - |
dc.date.accessioned | 2019-12-03T16:30:40Z | - |
dc.date.available | 2019-12-03T16:30:40Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 0893-7648 | - |
dc.identifier.issn | 1559-1182 | - |
dc.identifier.other | OAK-26117 | - |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/252354 | - |
dc.description.abstract | Chronic stress induces persistent depressive behaviors. Stress-induced transcriptional alteration over the homeostatic range in stress hormone-sensitive brain regions is believed to underlie long-lasting depressive behaviors. However, the detailed mechanisms by which chronic stress causes those adaptive changes are not clearly understood. In the present study, we investigated whether epigenetic changes regulate stress-induced depressive behaviors. We found that chronic stress in mice downregulates the epigenetic factors HDAC2 and SUV39H1 in the hippocampus. A series of follow-up analyses including ChIP assay and siRNA-mediated functional analyses reveal that glucocorticoids released by stress cumulatively increase Mkp-1 expression in the hippocampus, and increased Mkp-1 then debilitates p-CREB and PPAR gamma, which in turn suppress the epigenetic factors HDAC2 and SUV39H1. Furthermore, HDAC2 and SUV39H1 normally suppress the transcription of the Mkp-1, and therefore the reduced expression of HDAC2 and SUV39H1 increases Mkp-1 expression. Accordingly, repeated stress progressively strengthens a vicious cycle of the Mkp-1 signaling cascade that facilitates depressive behaviors. These results suggest that the hippocampal stress adaptation system comprising HDAC2/SUV39H1-regulated Mkp-1 signaling network determines the vulnerability to chronic stress and the maintenance of depressive behaviors. | - |
dc.language | English | - |
dc.publisher | SPRINGER | - |
dc.subject | Stress adaptation | - |
dc.subject | Epigenetic factors | - |
dc.subject | HDAC2 | - |
dc.subject | Mkp-1 | - |
dc.title | Stress-Induced Epigenetic Changes in Hippocampal Mkp-1 Promote Persistent Depressive Behaviors | - |
dc.type | Article | - |
dc.relation.issue | 12 | - |
dc.relation.volume | 56 | - |
dc.relation.index | SCIE | - |
dc.relation.index | SCOPUS | - |
dc.relation.startpage | 8537 | - |
dc.relation.lastpage | 8556 | - |
dc.relation.journaltitle | MOLECULAR NEUROBIOLOGY | - |
dc.identifier.doi | 10.1007/s12035-019-01689-4 | - |
dc.identifier.wosid | WOS:000494860800042 | - |
dc.identifier.scopusid | 2-s2.0-85068747183 | - |
dc.author.google | Lee, Jung-Eun | - |
dc.author.google | Kwon, Hye-Jin | - |
dc.author.google | Choi, Juli | - |
dc.author.google | Han, Pyung-Lim | - |
dc.contributor.scopusid | 한평림(7201947605) | - |
dc.date.modifydate | 20230901081001 | - |