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Optimal treatment of breast cancer in women older than 75 years: a Korea Breast Cancer Registry analysis

Title
Optimal treatment of breast cancer in women older than 75 years: a Korea Breast Cancer Registry analysis
Authors
Jeon, Ye WonYou, Sun HyongLee, Jong EunYoun, Hyun JoLim, WoosungHan, Jai HongPark, Chan HeunKim, Yong Seok
Ewha Authors
임우성
SCOPUS Author ID
임우성scopus
Issue Date
2019
Journal Title
BREAST CANCER RESEARCH AND TREATMENT
ISSN
0167-6806JCR Link

1573-7217JCR Link
Citation
BREAST CANCER RESEARCH AND TREATMENT vol. 178, no. 3, pp. 693 - 701
Keywords
Breast neoplasmsElderly womenAdjuvant treatmentSurvival
Publisher
SPRINGER
Indexed
SCI; SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Purpose The aim of this study was to investigate the therapeutic efficacy of adjuvant modalities for elderly Asian breast cancer patients using population-based data from the Korean Breast Cancer Registry database. Methods We identified 53,582 patients who underwent curative surgery between January 2005 and December 2010. The primary end point was the comparison of overall survival between the administration or omission of adjuvant treatment modalities, including endocrine treatment, radiation therapy, and chemotherapy, in the elderly group (older than 75 years) compared with the control group (younger than 75 years). Results Of the 53,582 patients analyzed, the total number of elderly patients was 901 (1.7%), and the number of control patients was 52,681 (98.3%). Although elderly patients were found to have larger tumor sizes (p = 0.024) and higher pathological stages (p < 0.001) than the control group, elderly patients were less likely to undergo adjuvant treatment compared to the control group. However, use of endocrine treatment in elderly patients with HR-positive breast cancer is associated with improved overall survival (OS) (adjusted OR 0.417; 95% confidence interval [CI] 0.240-0.726; p = 0.002). Furthermore, chemotherapy was associated with a significant improvement in OS in patients with stage II and III breast cancer (adjusted OR 0.657; 95% CI 0.462-0.934; p = 0.019). Conclusion Endocrine treatment and chemotherapy for elderly patients are associated with improved OS. Therefore, personalized decision-making based on the potential survival benefit of adjuvant treatment modalities should be made with the careful counseling of all elderly patients with breast cancer.
DOI
10.1007/s10549-019-05426-2
Appears in Collections:
의과대학 > 의학과 > Journal papers
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