Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김규보 | * |
dc.contributor.author | 김경수 | * |
dc.date.accessioned | 2019-12-03T16:30:36Z | - |
dc.date.available | 2019-12-03T16:30:36Z | - |
dc.date.issued | 2020 | * |
dc.identifier.issn | 0960-9776 | * |
dc.identifier.issn | 1532-3080 | * |
dc.identifier.other | OAK-26135 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/252337 | - |
dc.description.abstract | Purpose: This study evaluated the influence of prognostic factors and whole brain radiotherapy (WBRT) on overall survival (OS) of breast cancer (BC) patients with brain metastases (BM). Methods and materials: Medical records of 730 BC patients diagnosed with BM from 2000 to 2014 at 17 institutions were retrospectively reviewed. OS was calculated from BM diagnosis. Median follow-up duration was 11.9 months (range, 0.1-126.2). Results: Median OS was 15.0 months (95% CI: 14.0-16.9). Patients with different BC-specific graded prognostic assessment (GPA) scores showed significant differences (p < 0.001) in OS. In multivariate analysis, histologic grade 3 (p = 0.014), presence of extracranial metastasis (p <0.001), the number of BM (>4; p = 0.002), hormone receptor negativity (p = 0.005), HER2-negativity (p = 0.003), and shorter time interval (<30 months) between BC and BM diagnosis (p = 0.007) were associated with inferior OS. By summing the beta-coefficients of variables that were prognostic in multivariate analyses, we developed a prognostic model that stratified patients into low-risk (<= 0.673) and high-risk (>0.673) subgroups; the high-risk subgroup had poorer median OS (10.1 months, 95% CI: 7.9-11.9 vs. 21.9 months, 95% CI: 19.5 -27.1, p <0.001). Univariate and multivariate analyses of propensity score-matched patients diagnosed with BM >= 30 months after BC diagnosis (n = 389, "late BM") revealed that WBRT-treated patients showed superior OS compared to non-WBRT-treated patients (p = 0.070 and 0.030, respectively). Conclusion: Our prognostic model identified high-risk BC patients with BM who might benefit from increased surveillance; if validated, our model could guide treatment selection for such patients. Patients with late BM might benefit from WBRT as initial local treatment. (C) 2019 Elsevier Ltd. | * |
dc.language | English | * |
dc.publisher | CHURCHILL LIVINGSTONE | * |
dc.subject | Breast cancer | * |
dc.subject | Brain metastasis | * |
dc.subject | Overall survival | * |
dc.subject | Prognostic model | * |
dc.subject | Whole brain radiotherapy | * |
dc.title | Survival outcomes of breast cancer patients with brain metastases: A multicenter retrospective study in Korea (KROG 16-12) | * |
dc.type | Article | * |
dc.relation.volume | 49 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 41 | * |
dc.relation.lastpage | 47 | * |
dc.relation.journaltitle | BREAST | * |
dc.identifier.doi | 10.1016/j.breast.2019.10.007 | * |
dc.identifier.wosid | WOS:000512925000006 | * |
dc.identifier.scopusid | 2-s2.0-85074131659 | * |
dc.author.google | Kim, Jae Sik | * |
dc.author.google | Kim, Kyubo | * |
dc.author.google | Jung, Wonguen | * |
dc.author.google | Shin, Kyung Hwan | * |
dc.author.google | Im, Seock-Ah | * |
dc.author.google | Kim, Hee-Jun | * |
dc.author.google | Kim, Yong Bae | * |
dc.author.google | Chang, Jee Suk | * |
dc.author.google | Choi, Doo Ho | * |
dc.author.google | Park, Yeon Hee | * |
dc.author.google | Kim, Dae Yong | * |
dc.author.google | Kim, Tae Hyun | * |
dc.author.google | Choi, Byung Ock | * |
dc.author.google | Lee, Sea-Won | * |
dc.author.google | Kim, Suzy | * |
dc.author.google | Kwon, Jeanny | * |
dc.author.google | Kang, Ki Mun | * |
dc.author.google | Chung, Woong-Ki | * |
dc.author.google | Kim, Kyung Su | * |
dc.author.google | Nam, Ji Ho | * |
dc.author.google | Yoon, Won Sup | * |
dc.author.google | Kim, Jin Hee | * |
dc.author.google | Cha, Jihye | * |
dc.author.google | Oh, Yoon Kyeong | * |
dc.author.google | Kim, In Ah | * |
dc.contributor.scopusid | 김규보(8213302900) | * |
dc.contributor.scopusid | 김경수(57207404412) | * |
dc.date.modifydate | 20240318142630 | * |