View : 82 Download: 0

Incidence and characteristics of venous thromboembolism in Asian patients with primary central nervous system lymphoma undergoing chemotherapy

Title
Incidence and characteristics of venous thromboembolism in Asian patients with primary central nervous system lymphoma undergoing chemotherapy
Authors
Byun J.M.Hong J.Yoon S.-S.Koh Y.Ock C.-Y.Kim T.M.Lee J.H.Kim S.-H.Lee J.-O.Bang S.-M.Yhim H.-Y.Bae S.H.Korean Thrombosis and Hemostasis Working Party of Korean Society of HematologyMun Y.-C.Oh D.
Ewha Authors
문영철
SCOPUS Author ID
문영철scopus
Issue Date
2019
Journal Title
Thrombosis Research
ISSN
0049-3848JCR Link
Citation
Thrombosis Research vol. 183, pp. 131 - 135
Keywords
AsianIncidencePrimary central nervous system lymphomaRisk factorVenous thromboembolism
Publisher
Elsevier Ltd
Indexed
SCI; SCIE; SCOPUS scopus
Document Type
Article
Abstract
Background: Venous thromboembolism (VTE) may lead to diminished quality of life and ultimately worse prognosis in cancer patients, but there is limited data on the incidence, risk factors and mortality impact of VTE in Asian primary central nervous system lymphoma (PCNSL) patients. Objectives: To report the incidence, risk factors and mortality impact of VTE in Asian PCNSL patients. Methods: From 7 academic centers in Korea, 235 newly diagnosed PCNSL patients undergoing chemotherapy were retrospectively identified during period of January 2004 to September 2018. Results: All patients but 12 (6 T-cell, 6 other B-cell) had diffuse large B-cell lymphoma. During the median follow-up of 21 months, 33 patient (14.0%) developed VTE. Of the VTE events, 11 (33.3%) were deep vein thrombosis (DVT), 15 (45.5%) were pulmonary thromboembolism (PTE), and 7 (21.2%) were DVT with PTE. The median time to VTE was 2 months and the one-year actuarial incidence was 11.7%. On multivariate analysis, ECOG performance ≥2, age >60 years, female sex, and Hb <10 g/dL were independently associated with VTE. The patients with VTE were associated with shorter disease specific survival (P = 0.046) and overall survival (P = 0.022). Conclusion: Overall, the incidence of VTE in Asian PCNSL seems to be lower compared to Western population. As VTE development is associated with overall survival and indicative of relapse, careful close monitoring is warranted. © 2019 Elsevier Ltd
DOI
10.1016/j.thromres.2019.10.002
Appears in Collections:
의과대학 > 의학과 > Journal papers
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML


qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE