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Constituents of the leaves and twigs of Elaeagnus umbellata and their proliferative effects on human keratinocyte HaCaT cells

Title
Constituents of the leaves and twigs of Elaeagnus umbellata and their proliferative effects on human keratinocyte HaCaT cells
Authors
Paudel, Sunil BabuPark, JiyoungKim, Nam HeeChoi, HyukjaeSeo, Eun-KyoungWoo, Hyun AeNam, Joo-Won
Ewha Authors
서은경우현애
SCOPUS Author ID
서은경scopus; 우현애scopus
Issue Date
2019
Journal Title
FITOTERAPIA
ISSN
0367-326XJCR Link

1873-6971JCR Link
Citation
FITOTERAPIA vol. 139
Keywords
Elaeagnus umbellataElaeagnaceaeSerotonin derivativeFlavonoid glycosideCell proliferationHaCaT keratinocyte
Publisher
ELSEVIER
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Bioassay-guided fractionation of an extract of leaves and twigs of Elaeagnus umbellata led to the isolation of a serotonin derivative, N-[2-(5-hydroxyl-1H-indol-3-yl)ethyl]-butanamide (1), along with six flavonoid glycosides, kaempferol-3-O-beta-D-xylopyranosyl(1 -> 2)-beta-D-galactopyranoside-7-O-alpha-L-rhamnopyranoside (2), kaempferol-3-O-beta-D-galactopyranoside-7-O-alpha-L-rhamnopyranoside (3), kaempferol-3-O-alpha-L-rhamnopyranosyl(1 -> 6)-beta-D-galactopyranoside-7-O-alpha-L-rhamnopyranoside (4), kaempferol-3-O-beta-D-xylopyranosyl(1 -> 2)-beta-D-galactopyranoside (5), kaempferol-3-O-rutinoside (6), and kaempferol-3-O-beta-D-glucopyranosyl(1 -> 2)-beta-D-galactopyranoside-7-O-alpha-L-rhamnopyranoside (7). Their structures were elucidated using 1D/2D nuclear magnetic resonance spectroscopy and mass spectrometry. Compounds 1-6 were evaluated for their proliferative effects on HaCaT keratinocytes; 1-5 promoted keratinocyte proliferation dose dependently. Compounds 3 and 4 showed potent activities. These results suggest that the leaves and twigs of E. umbellata have wound healing and skin cell regeneration potentials.
DOI
10.1016/j.fitote.2019.104374
Appears in Collections:
약학대학 > 약학과 > Journal papers
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