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Pharmacokinetic Alteration of Paclitaxel by Ferulic Acid Derivative

Title
Pharmacokinetic Alteration of Paclitaxel by Ferulic Acid Derivative
Authors
Lee, JaeokChae, Song WhaMa, LianJiLim, So YeonAlnajjar, SarahChoo, Hea-Young ParkLee, Hwa JeongRhie, Sandy Jeong
Ewha Authors
박혜영이화정이정연이재옥
SCOPUS Author ID
박혜영scopus; 이화정scopus; 이정연scopus
Issue Date
2019
Journal Title
PHARMACEUTICS
ISSN
1999-4923JCR Link
Citation
PHARMACEUTICS vol. 11, no. 11
Keywords
ferulic acid derivativesP-glycoproteineliminationpharmacokineticsbioavailabilitypaclitaxel
Publisher
MDPI
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
P-glycoprotein (P-gp) is known to be involved in multidrug resistance (MDR) and modulation of pharmacokinetic (PK) profiles of substrate drugs. Here, we studied the effects of synthesized ferulic acid (FA) derivatives on P-gp function in vitro and examined PK alteration of paclitaxel (PTX), a well-known P-gp substrate drug by the derivative. Compound 5c, the FA derivative chosen as a significant P-gp inhibitor among eight FA candidates by in vitro results, increased PTX AUC(inf) as much as twofold versus the control by reducing PTX elimination in rats. These results suggest that FA derivative can increase PTX bioavailability by inhibiting P-gp existing in eliminating organs.
DOI
10.3390/pharmaceutics11110593
Appears in Collections:
약학대학 > 약학과 > Journal papers
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