A simple decontamination procedure for unintended iodide impurity during [C-11]methionine production

Abstract

A solid-phase extraction cartridge method is a widely used carbon-11 labeling method for obtaining [C-11]methionine. Although the process is convenient and efficient, unintended impurity sometimes observed in the final product owing to contamination by volatile iodide generated during [C-11]CH3I production. Herein, we suggest a simple method to eliminate impurities contained in [C-11]methionine solution using an anion-exchange resin cartridge.