Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 이지희 | * |
dc.contributor.author | 이진화 | * |
dc.contributor.author | 안영호 | * |
dc.contributor.author | 김용배 | * |
dc.date.accessioned | 2019-12-03T16:30:17Z | - |
dc.date.available | 2019-12-03T16:30:17Z | - |
dc.date.issued | 2019 | * |
dc.identifier.issn | 1672-7681 | * |
dc.identifier.other | OAK-26068 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/252274 | - |
dc.description.abstract | Apoptotic cell clearance by phagocytes is essential in tissue homeostasis. We demonstrated that conditioned medium (CM) from macrophages exposed to apoptotic cancer cells inhibits the TGFβ1-induced epithelial–mesenchymal transition (EMT), migration, and invasion of cancer cells. Apoptotic 344SQ (ApoSQ) cell-induced PPARγ activity in macrophages increased the levels of PTEN, which was secreted in exosomes. Exosomal PTEN was taken up by recipient lung cancer cells. ApoSQ-exposed CM from PTEN knockdown cells failed to enhance PTEN in 344SQ cells, restore cellular polarity, or exert anti-EMT and anti-invasive effects. The CM that was deficient in PPARγ ligands, including 15-HETE, lipoxin A4, and 15d-PGJ2, could not reverse the suppression of PPARγ activity or the PTEN increase in 344SQ cells and consequently failed to prevent the EMT process. Moreover, a single injection of ApoSQ cells inhibited lung metastasis in syngeneic immunocompetent mice with enhanced PPARγ/PTEN signaling both in tumor-associated macrophages and in tumor cells. PPARγ antagonist GW9662 reversed the signaling by PPARγ/PTEN; the reduction in EMT-activating transcription factors, such as Snai1 and Zeb1; and the antimetastatic effect of the ApoSQ injection. Thus, the injection of apoptotic lung cancer cells may offer a new strategy for the prevention of lung metastasis. © 2019, The Author(s). | * |
dc.language | English | * |
dc.publisher | Chinese Soc Immunology | * |
dc.subject | Apoptotic cell clearance | * |
dc.subject | EMT | * |
dc.subject | Exosomal PTEN | * |
dc.subject | Metastasis | * |
dc.subject | PPARγ ligands | * |
dc.title | Programming of macrophages by UV-irradiated apoptotic cancer cells inhibits cancer progression and lung metastasis | * |
dc.type | Article | * |
dc.relation.issue | 11 | * |
dc.relation.volume | 16 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 851 | * |
dc.relation.lastpage | 867 | * |
dc.relation.journaltitle | Cellular and Molecular Immunology | * |
dc.identifier.doi | 10.1038/s41423-019-0209-1 | * |
dc.identifier.wosid | WOS:000494946200004 | * |
dc.identifier.scopusid | 2-s2.0-85062549840 | * |
dc.author.google | Kim Y.-B. | * |
dc.author.google | Ahn Y.-H. | * |
dc.author.google | Jung J.-H. | * |
dc.author.google | Lee Y.-J. | * |
dc.author.google | Lee J.-H. | * |
dc.author.google | Kang J.L. | * |
dc.contributor.scopusid | 이지희(7404517577) | * |
dc.contributor.scopusid | 이진화(56646645800;58376333800) | * |
dc.contributor.scopusid | 안영호(7202402440) | * |
dc.contributor.scopusid | 김용배(57225051380) | * |
dc.date.modifydate | 20240222132209 | * |