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Low bone mineral density of vertebral lateral projections can predict spinal radiographic damage in patients with ankylosing spondylitis
- Low bone mineral density of vertebral lateral projections can predict spinal radiographic damage in patients with ankylosing spondylitis
- Kim, Ji-Won; Chung, Min Kyung; Lee, Jennifer; Kwok, Seung-Ki; Kim, Wan-Uk; Park, Sung-Hwan; Ju, Ji Hyeon
- Ewha Authors
- Issue Date
- Journal Title
- CLINICAL RHEUMATOLOGY
- CLINICAL RHEUMATOLOGY vol. 38, no. 12, pp. 3567 - 3574
- Ankylosing spondylitis; Bone density; Disease progression; Osteoporosis
- SPRINGER LONDON LTD
- SCIE; SCOPUS
- Document Type
- Objectives To investigate the association between bone mineral status and spinal radiographic damage in patients with ankylosing spondylitis (AS) and determine whether bone mineral status can predict further spinal radiographic damage after 2 years. Methods Bone mineral density (BMD) of the lumbar spine (anteroposterior and lateral projections), femoral neck, and total hip and trabecular bone score (TBS) of the lumbar spine were measured in AS patients (n = 54) who fulfilled the modified New York criteria. Spinal radiographic damage was scored on cervical and lumbar spine radiographs using modified Stoke Ankylosing Spondylitis Spinal Score (mSASSS) at baseline and after 2 years. Simple and multiple linear regression analyses were performed to examine predictors of spinal radiographic damage. Results Patients with advanced AS exhibited low BMD on lumbar spine lateral projections, femoral neck, and total hip and low TBS. Low vertebral bone mass at baseline, assessed by BMD of the lateral projections or TBS, was independently associated with baseline mSASSS. After 2 years, mSASSS change from baseline was significantly associated with high baseline mSASSS, high baseline erythrocyte sedimentation rate and C-reactive protein (CRP) levels, and low baseline BMD of the lumbar spine lateral projections. The best predictive model for spinal radiographic progression consisted of baseline mSASSS, baseline CRP, and low BMD of lateral lumbar spine (area under curve = 0.826). Conclusions BMD at vertebral lateral projections and TBS were inversely associated with baseline mSASSS in AS patients. Low BMD at vertebral lateral projections, as well as baseline mSASSS and inflammatory markers, might predict spinal radiographic damage in AS.
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