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MicroRNA-196A-2 Polymorphisms and Hepatocellular Carcinoma in Patients With Chronic Hepatitis B
- Title
- MicroRNA-196A-2 Polymorphisms and Hepatocellular Carcinoma in Patients With Chronic Hepatitis B
- Authors
- Kim, Hwi Young; Yoon, Jung-Hwan; Lee, Hyo-Suk; Cheong, Jae Youn; Cho, Sung Won; Shin, Hyoung Doo; Kim, Yoon Jun
- Ewha Authors
- 김휘영
- SCOPUS Author ID
- 김휘영
- Issue Date
- 2014
- Journal Title
- JOURNAL OF MEDICAL VIROLOGY
- ISSN
- 0146-6615
1096-9071
- Citation
- JOURNAL OF MEDICAL VIROLOGY vol. 86, no. 3, pp. 446 - 453
- Keywords
- polymorphism; microRNA; hepatitis B; liver cancer
- Publisher
- WILEY
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- Single nucleotide polymorphisms (SNPs) in microRNA (miR)-196a-2 have been suggested to contribute to susceptibility to various human cancers. The aim of this study was to determine whether polymorphisms of miRNA-196a-2 affect the clinical outcomes of hepatitis B virus (HBV) infection in Korean patients. Genotyping was performed for 1,439 Korean patients with either past or present HBV infection, including 404 control subjects who underwent spontaneous recovery and 1,035 subjects with chronic HBV (313 cases of chronic hepatitis B, 305 cases of cirrhosis of the liver, and 417 cases of hepatocellular carcinoma [HCC]). Genotyping results revealed that the polymorphism rs12304647A>C, which lies in the pri-miRNA region of miR-196a-2, has a significant minor allele frequency (0.210). Logistic analysis revealed that the rs12304647A>C SNP was associated with a significant protective effect against HCC in patients with chronic hepatitis (odds ratio [OR]=0.70, P=0.005 in a codominant model; OR=0.73, P=0.03 in a dominant model; OR=0.31, P=0.004 in a recessive model), and in the patients with cirrhosis (OR=0.63, P=0.0009 in a codominant model; OR=0.66, P=0.01 in a dominant model; OR=0.25, P=0.001 in a recessive model). A Cox relative hazards model with adjustments for age, gender, HBeAg status, and cirrhosis revealed that rs12304647A>C retained its association with HCC in a codominant model (relative hazards [RH]=1.14, P=0.05) and in a recessive model (RH=1.44, P=0.03). However, the miR-196a-2 rs12304647A>C SNP had no association with HBV clearance. In conclusion, the miR-196a-2 rs12304647 CC genotype had a protective effect against development of HCC in comparison to the AA or AC genotypes in patients with chronic hepatitis and cirrhosis. J. Med. Virol. 86:446-453, 2014. (c) 2013 Wiley Periodicals, Inc.
- DOI
- 10.1002/jmv.23848
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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