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Histopathologic factors affecting tumor recurrence after hepatic resection in colorectal liver metastases

Title
Histopathologic factors affecting tumor recurrence after hepatic resection in colorectal liver metastases
Authors
Park, Min-SuYi, Nam-JoonSon, Sang-YongYou, TaeSuh, Suk-WonChoi, Young RokKim, HyeyoungHong, GeunLee, Kyoung BunLee, Kwang-WoongJeong, Seung-YongPark, Kyu JooSuh, Kyung-SukPark, Jae-Gahb
Ewha Authors
홍근
SCOPUS Author ID
홍근scopus
Issue Date
2014
Journal Title
ANNALS OF SURGICAL TREATMENT AND RESEARCH
ISSN
2288-6575JCR Link

2288-6796JCR Link
Citation
ANNALS OF SURGICAL TREATMENT AND RESEARCH vol. 87, no. 1, pp. 14 - 21
Keywords
Colorectal neoplasmLiver metastasisRecurrenceHepatic resectionInflammation
Publisher
KOREAN SURGICAL SOCIETY
Indexed
SCIE; SCOPUS; KCI WOS
Document Type
Article
Abstract
Purpose: Hepatic resection is a standard method of treatment for colorectal liver metastases (CRLM). However, the pathologic factors of metastatic lesions that affect tumor recurrence are less well defined in CRLM. The aim of this study was to evaluate the risk factors for recurrence of CRLM, focusing on histopathologic factors of metastatic lesions of the liver. Methods: From January 2003 to December 2008, 117 patients underwent curative hepatic resection for CRLM were reviewed. Tumor size and number, differentiation, tumor budding, angio-invasion, dedifferentiation and tumor infiltrating inflammation of metastatic lesions were investigated. Results: The mean number of hepatic tumors was 2 (range, 1-8). The mean size of the largest tumor was 2.9 cm (range, 0.3-18.5 cm) in diameter. The moderate differentiation of the hepatic tumor was the most common in 86.3% of the patients. Tumor budding, angio-invasion, and dedifferentiation were observed in 81%, 34%, and 12.8% of patients: Inflammation infiltrating tumor was detected in 6.8% of patients. Recurrence after hepatic resection appeared in 69 out of 117 cases (58.9%). Recurrence-free survival at 1, 2 and 5 years were 62.4%, 43.6%, and 34.3%. The multivariate analysis showed the number of metastases >= 3 (P = 0.007), the tumor infiltrating inflammation (P = 0.047), and presence of dedifferentiation (P = 0.020) to be independent risk factors for tumor recurrence. Conclusion: Histopathological factors, i.e., dedifferentiation and tumor infiltrating inflammation of the metastatic lesion, could be one of the risk factors of aggressive behavior as well as the number of metastases even after curative resection for CRLM.
DOI
10.4174/astr.2014.87.1.14
Appears in Collections:
의과대학 > 의학과 > Journal papers
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