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Fulminant hepatitis linked to dapsone hypersensitivity syndrome requiring urgent living donor liver transplantation: A case report
- Fulminant hepatitis linked to dapsone hypersensitivity syndrome requiring urgent living donor liver transplantation: A case report
- Garcia, Angelica; Yi, Nam-Joon; Lee, Kyoung Bun; Lee, Jeong-Moo; Choi, Young Rok; Suh, Suk-Won; You, Tae; Lee, Kwang-Woong; Park, June Dong; Kang, Hyoung Jin; Kim, Joon Gon; Kang, Eun Kyeong; Hong, Geun; Suh, Kyung-Suk
- Ewha Authors
- SCOPUS Author ID
- Issue Date
- Journal Title
- PEDIATRIC TRANSPLANTATION
- PEDIATRIC TRANSPLANTATION vol. 18, no. 7, pp. E240 - E245
- fulminant hepatitis; dapsone hypersensitivity syndrome; liver transplant; pigmented purpuric dermatosis
- SCIE; SCOPUS
- Document Type
- Dapsone is a sulfone-type drug used widely for different infectious, immune, and hypersensitivity disorders as an antibacterial treatment alone or in combination for leprosy and sometimes for infected skin lesions. DHS is a severe idiosyncratic adverse reaction with multi-organ involvement. However, acute necrotic hepatitis requiring an emergent LT is rare. Herein, we report a case of 12-yr-old girl who suffered from fulminant hepatitis and multi-organ failure due to DHS for PPD. She was saved by emergent LDLT. A high index of suspicion and rapid diagnosis are necessary not to miss this potentially lethal but rare disease.
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