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Synthesis of Antifungal Evaluation of 2H-[1,2,3]Triazolo[4,5-g]isoquinoline-4,9-diones
- Title
- Synthesis of Antifungal Evaluation of 2H-[1,2,3]Triazolo[4,5-g]isoquinoline-4,9-diones
- Authors
- Ryu, Chung-Kyu; Oh, Sun Young; Choi, Soo Jung; Kang, Da Young
- Ewha Authors
- 유충규
- SCOPUS Author ID
- 유충규
- Issue Date
- 2014
- Journal Title
- CHEMICAL & PHARMACEUTICAL BULLETIN
- ISSN
- 0009-2363
- Citation
- CHEMICAL & PHARMACEUTICAL BULLETIN vol. 62, no. 11, pp. 1119 - 1124
- Keywords
- antimicrobial; antifungal; fungus; 2H-[1,2,3]triazolo[4,5-g]isoquinoline-4,9-dione
- Publisher
- PHARMACEUTICAL SOC JAPAN
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- 2H-[1,2,3]Triazolo[4,5-g]isoquinoline-4,9-diones and 2H-[1,2,3]triazolo[4,5-g]quinoline-4,9-diones were synthesized and tested for in vitro antifungal activity against pathogenic fungi. Many of those synthesized showed potent antifungal activity. Compounds 3a, 3b, 3g, and 3h completely inhibited the growth of all fungal species tested at the MIC level of 0.8-12.5 mu g/mL. The results suggest that 2H-[1,2,3]triazolo[4,5-g]-isoquinoline-4,9-diones could be antifungal agents.
- DOI
- 10.1248/cpb.c14-00527
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
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