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Positive association between serious psychiatric outcomes and complications of diabetes mellitus in patients with depressive disorders

Title
Positive association between serious psychiatric outcomes and complications of diabetes mellitus in patients with depressive disorders
Authors
Kim, Gyung-MeeWoo, Jong-MinJung, Sun-YoungShin, SangjinSong, Hyun JinPark, JooyeonAhn, Jeonghoon
Ewha Authors
안정훈
SCOPUS Author ID
안정훈scopus
Issue Date
2015
Journal Title
INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE
ISSN
0091-2174JCR Link

1541-3527JCR Link
Citation
INTERNATIONAL JOURNAL OF PSYCHIATRY IN MEDICINE vol. 50, no. 2, pp. 131 - 146
Keywords
Depressiondiabetescomorbidityserious outcomes
Publisher
SAGE PUBLICATIONS INC
Indexed
SCIE; SSCI; SCOPUS WOS
Document Type
Article
Abstract
Objectives Depression and diabetes are closely biologically and behaviorally intertwined. We examined the impact of comorbid diabetes mellitus on the incidence of serious psychiatric outcomes among patients with depression. Methods We used claims data from the Korean Health Insurance Review & Assessment Service database of patients who were diagnosed with depression within one year of an index prescription for antidepressants between January 2007 and June 2008. We investigated the association between the comorbidity of diabetes mellitus and serious psychiatric outcomes of depression, such as psychiatric hospitalization, psychiatric emergency room visits, and suicide attempts. Results Among 200,936 patients with depression, 74,160 (36.9%) had diabetes mellitus, including 57,418 (28.6%) with complications. The incidence of serious psychiatric outcomes was 3.3% in patients with depression without diabetes and 6.7% in patients with depression and diabetes mellitus. Patients with depression and diabetes mellitus complications showed higher rates of serious outcomes than that did those without diabetes mellitus complications (odds ratio, 1.19; 95% confidence interval, 1.11-1.13). Similarly, depressed patients with micro and macrovascular diabetic complications were more likely to experience serious outcomes than those without diabetes mellitus complications (odds ratio, 2.2; 95% confidence interval, 2.07-2.34). Conclusions Our results showed that comorbid diabetes mellitus can increase the risk of serious outcomes of depression, such as suicide and hospitalization, and thus may alter the antidepressants prescription patterns and healthcare service use among patients with depressive disorders.
DOI
10.1177/0091217415605024
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신산업융합대학 > 융합보건학과 > Journal papers
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