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Clinicopathological characteristics and treatment outcomes of 38 cases of primary thyroid lymphoma: a multicenter study
- Title
- Clinicopathological characteristics and treatment outcomes of 38 cases of primary thyroid lymphoma: a multicenter study
- Authors
- Chai, Young Jun; Hong, Jun Hyun; Koo, Do Hoon; Yu, Hyeong Won; Lee, Joon-Hyop; Kwon, Hyungju; Kim, Su-jin; Choi, June Young; Lee, Kyu Eun
- Ewha Authors
- 권형주
- SCOPUS Author ID
- 권형주
- Issue Date
- 2015
- Journal Title
- ANNALS OF SURGICAL TREATMENT AND RESEARCH
- ISSN
- 2288-6575
2288-6796
- Citation
- ANNALS OF SURGICAL TREATMENT AND RESEARCH vol. 89, no. 6, pp. 295 - 299
- Keywords
- Lymphoma; Thyroid lymphoma; Primary thyroid lymphoma; Marginal zone B-cell lymphoma; Diffuse Large B-cell lymphoma
- Publisher
- KOREAN SURGICAL SOCIETY
- Indexed
- SCIE; SCOPUS; KCI
- Document Type
- Article
- Abstract
- Purpose: Primary thyroid lymphoma (PTL) is a rare disease and it has been investigated in a limited number of studies. The present multicenter study evaluated the clinical features and treatment outcomes of PTL. Methods: The medical records of patients diagnosed with PTL between 2000 and 2013 in three centers were retrospectively reviewed. Results: The study included 11 men and 27 women with a median age of 63.3 years (range, 42-83 years). The median follow-up was 56.0 months (range, 3-156 months). Of the 38 patients included, 16 had mucosa-associated lymphoid tissue (MALT) lymphoma, six had mixed MALT and diffuse large B-cell lymphoma (DLBCL), and 16 had DLBCL. Thirty-five patients (92.1%) had early stage (stage I/II) disease. Of the 16 MALT lymphoma patients, 14 were treated by surgery, and radiotherapy (RT) or chemotherapy was combined in five patients. Two patients received RT or chemotherapy alone. Of the six mixed MALT and DLBCL patients, three underwent surgery with chemotherapy and three underwent chemotherapy alone, RT alone, or surgery with RT. All of the 16 DLBCL patients received chemotherapy, and surgery and RT was combined in 4 and 1 patients, respectively. The 5-year survival was 100% for MALT lymphoma (7 of 7) and mixed MALT and DLBCL patients (5 of 5) and 87.5% for DLBCL patients (7 of 8). Conclusion: Early stage PTL has an excellent prognosis when managed by single or combined treatment modalities. Clinicians should consider PTL in patients with underlying Hashimoto's thyroiditis presenting with an enlarging thyroid mass.
- DOI
- 10.4174/astr.2015.89.6.295
- Appears in Collections:
- 의과대학 > 의학과 > Journal papers
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