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Effect of Hashimoto thyroiditis on low-dose radioactive-iodine remnant ablation

Title
Effect of Hashimoto thyroiditis on low-dose radioactive-iodine remnant ablation
Authors
Kwon, HyungjuChoi, June YoungMoon, Jae HoonPark, Hyo JinLee, Won WooLee, Kyu Eun
Ewha Authors
권형주
SCOPUS Author ID
권형주scopus
Issue Date
2016
Journal Title
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK
ISSN
1043-3074JCR Link

1097-0347JCR Link
Citation
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK vol. 38, pp. E730 - E735
Keywords
radioiodineablationlow dosepapillary thyroid carcinomaHashimoto thyroiditis
Publisher
WILEY
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
Background. Radioactive-iodine remnant ablation is an integral part of the papillary thyroid carcinoma (PTC) treatment. Although a minimum dose is usually recommended, there is controversy as to whether the low-dose (1100 MBq) radioactive-iodine remnant ablation is adequate for selected patients. Methods. A retrospective cohort study was conducted on 691 patients. Patients with no remnant thyroid on the follow-up whole body scan and low stimulated thyroglobulin (sTg) level (<2.0 ng/mL) were deemed as successful treatment cases. Results. Initial low-dose radioactive-iodine remnant ablation was successful in 431 patients (62.3%). Multivariate analysis demonstrated a negative correlation between successful radioactive-iodine remnant ablation and coexisting Hashimoto thyroiditis based on histopathology diagnosis (odds ratio [ OR] 53.23; p < .001) as well as elevated preablation sTg (OR51.24; p < .001). Conclusion. Our data suggest that coexisting Hashimoto thyroiditis and elevated sTg are negative predictive factors for successful low-dose radioactive-iodine remnant ablation treatment. An appropriate risk-adjusted approach may improve the efficacy of radioactive-iodine remnant ablation treatment. (C) 2015 Wiley Periodicals, Inc.
DOI
10.1002/hed.24080
Appears in Collections:
의과대학 > 의학과 > Journal papers
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