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Proton pump inhibitors and risk of Clostridium difficile infection: a multi-country study using sequence symmetry analysis

Title
Proton pump inhibitors and risk of Clostridium difficile infection: a multi-country study using sequence symmetry analysis
Authors
Roughead, Elizabeth E.Chan, Esther W.Choi, Nam-KyongGriffiths, JennaJin, Xue-MeiLee, JoongyubKimura, MichioKimura, TomomiKubota, KiyoshiLai, Edward Chia-ChengMan, Kenneth K. C.Tuan Anh NguyenOoba, NobuhiroPark, Byung-JooSato, TsugumichiShin, Ju-YoungWang, TongTongWong, Ian C. K.Yang, Yea-Huei KaoPratt, Nicole L.
Ewha Authors
최남경
Issue Date
2016
Journal Title
EXPERT OPINION ON DRUG SAFETY
ISSN
1474-0338JCR Link

1744-764XJCR Link
Citation
EXPERT OPINION ON DRUG SAFETY vol. 15, no. 12, pp. 1589 - 1595
Keywords
Proton pump inhibitorsClostridium difficileadverse eventAsiasequence symmetry analysis
Publisher
TAYLOR &

FRANCIS LTD
Indexed
SCIE; SCOPUS WOS
Document Type
Review
Abstract
Objective: To determine the association between incident proton pump inhibitor (PPI) use and Clostridium difficile infections across multiple countries Method: National data covering the total population in Australia and Korea, the Canadian population over 65 years and a 3 million person random sample data set from Taiwan were assessed, as were data from a worker insurance population and a hospital inpatient/outpatient population in Japan. Sequence symmetry analysis was used to assess the association with oral vancomycin dispensing as the outcome of interest. Results: 54,957 patients were included. Positive associations were observed in Australia; adjusted sequence ratio (ASR) 2.48 (95% CI 1.90, 3.12), Korea ASR 2.15 (95% CI 2.11, 2.19), Canada ASR 1.45 (95% CI 1.16, 1.79), Japan hospital dataset ASR 3.21 (95% CI 2.12, 4.55) and Japan worker insurance dataset ASR 5.40 (95% CI 2.73, 8.75). The pooled result was ASR 2.40 (95% CI 1.88, 3.05) and 3.16 (95% CI 1.95, 5.10) when limited to Japan, Korean and Taiwan. Results did not vary by individual PPI. The temporal analysis showed effects within the first two weeks of PPI initiation. Conclusion: Our study confirms the association between PPI initiation and C. difficile infections across countries in the Asia-Pacific region.
DOI
10.1080/14740338.2016.1238071
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신산업융합대학 > 융합보건학과 > Journal papers
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