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Free triiodothyronine/free thyroxine ratio rather than thyrotropin is more associated with metabolic parameters in healthy euthyroid adult subjects

Title
Free triiodothyronine/free thyroxine ratio rather than thyrotropin is more associated with metabolic parameters in healthy euthyroid adult subjects
Authors
Park, So YoungPark, Se EunJung, Sang WonJin, Hyun SeokPark, Ie ByungAhn, Song VogueLee, Sihoon
Ewha Authors
안성복
Issue Date
2017
Journal Title
CLINICAL ENDOCRINOLOGY
ISSN
0300-0664JCR Link

1365-2265JCR Link
Citation
CLINICAL ENDOCRINOLOGY vol. 87, no. 1, pp. 87 - 96
Keywords
FT3/FT4 ratiometabolic syndromethyroid hormoneTSH
Publisher
WILEY
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
ObjectiveThe interrelation between TSH, thyroid hormones and metabolic parameters is complex and has not been confirmed. This study aimed to determine the association of TSH and thyroid hormones in euthyroid subjects and the relationship between thyroid function and metabolic risk factors. Furthermore, this study examined whether thyroid function has predictive power for metabolic syndrome. DesignThis is a cross-sectional study that included subjects in a medical health check-up programme at a single institution. PatientsThe study included 132346 participants (66991 men and 65355 women) aged over 18years who had TSH, free T4 (FT4) and free T3 (FT3) levels within the institutional reference ranges. MeasurementsThyrotropin, FT4, FT3 and metabolic parameters including height, weight, waist circumference, blood pressure, serum levels of total cholesterol, triglyceride, high-density lipoprotein cholesterol, insulin and glucose were measured. ResultsThere was a positive association between FT3/FT4 ratio and TSH in both men and women after adjusting for age, body mass index, smoking status and menopausal status (in women). The FT3/FT4 ratio and TSH were positively associated with risk of metabolic syndrome parameters including insulin resistance. The FT3/FT4 ratio had a greater predictive power than TSH for metabolic syndrome in both men and women. ConclusionsThyrotropin levels were positively associated with FT3/FT4 ratio within the euthyroid range. The higher FT3/FT4 ratio is associated with increased risk of metabolic syndrome parameters and insulin resistance. FT3/FT4 ratio has a better predictive power for metabolic syndrome than TSH.
DOI
10.1111/cen.13345
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신산업융합대학 > 융합보건학과 > Journal papers
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