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Association between Nitrogen Stable Isotope Ratios in Human Hair and Serum Levels of Leptin

Title
Association between Nitrogen Stable Isotope Ratios in Human Hair and Serum Levels of Leptin
Authors
Ahn, Song VogueKoh, Sang-BaekLee, Kwang-SikBong, Yeon-SikPark, Jong-Ku
Ewha Authors
안성복
Issue Date
2017
Journal Title
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
ISSN
0040-8727JCR Link

1349-3329JCR Link
Citation
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE vol. 243, no. 2, pp. 133 - 139
Keywords
carbonleptinmetabolismnitrogenstable isotope ratio
Publisher
TOHOKU UNIV MEDICAL PRESS
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
Stable isotope ratios have been reported to be potential biomarkers of dietary intake and nutritional status. High serum levels of leptin, a hormone which regulates energy metabolism and food intake, are associated with insulin resistance and metabolic syndrome. However, little is known about the association between stable isotope ratios and the metabolic risk in humans. We investigated whether the carbon and nitrogen stable isotope ratios in hair are associated with serum leptin levels. Hair samples were collected from 399 healthy adults (233 men and 166 women) aged 40 to 70 years of a community-based cohort in Korea and the bulk stable isotope ratios of carbon (PC) and nitrogen (delta N-15) were measured for all hair samples. Serum leptin levels were analyzed by radioimmunoassay. delta N-15 showed positive correlations with serum leptin levels. In multivariate models, increasing delta N-15 were associated with elevated serum leptin levels (defined as the median values), whereas delta C-13 were not significantly associated with serum leptin levels. The odds ratio (95% confidence interval) per 1% increase in delta(NI)-N-15 for an elevated serum leptin level was 1.58 (1.11-2.26). In participants with high body mass index, delta N-15 showed positive associations with serum leptin levels, whereas these associations were not seen in participants with low body mass index. The nitrogen stable isotopic ratio in hair is positively associated with serum leptin levels. The hair delta N-15 could be used as a clinical marker to estimate metabolic risk.
DOI
10.1620/tjem.243.133
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신산업융합대학 > 융합보건학과 > Journal papers
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