Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 서주영 | * |
dc.contributor.author | 우소연 | * |
dc.date.accessioned | 2019-11-14T16:31:34Z | - |
dc.date.available | 2019-11-14T16:31:34Z | - |
dc.date.issued | 2015 | * |
dc.identifier.issn | 1933-0219 | * |
dc.identifier.issn | 1935-3456 | * |
dc.identifier.other | OAK-15203 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/251818 | - |
dc.description.abstract | Eosinophils are multifunctional leukocytes that reside in the gastrointestinal (GI) lamina propria, where their basal function remains largely unexplored. In this study, by examining mice with a selective deficiency of systemic eosinophils (by lineage ablation) or GI eosinophils (eotaxin-1/2 double deficient orCC chemokine receptor 3 deficient), we show that eosinophils support immunoglobulin A (IgA) class switching, maintain intestinal mucus secretions, affect intestinal microbial composition, and promote the development of Peyer's patches. Eosinophil-deficient mice showed reduced expression of mediators of secretory IgA production, including intestinal interleukin 1 beta (IL-1 beta), inducible nitric oxide synthase, lymphotoxin (LT) alpha, and LT-beta, and reduced levels of retinoic acid-related orphan receptor gamma t-positive (ROR-gamma t(+)) innate lymphoid cells (ILCs), while maintaining normal levels of APRIL (a proliferation-inducing ligand), BAFF (B cell-activating factor of the tumor necrosis factor family), and TGF-beta (transforming growth factor beta). GI eosinophils expressed a relatively high level of IL-1 beta, and IL-1 beta-deficient mice manifested the altered gene expression profiles observed in eosinophil-deficient mice and decreased levels of IgA(+) cells and ROR-gamma t(+) ILCs. On the basis of these collective data, we propose that eosinophils are required for homeostatic intestinal immune responses including IgA production and that their affect is mediated via IL-1 beta in the small intestine. | * |
dc.language | English | * |
dc.publisher | NATURE PUBLISHING GROUP | * |
dc.title | IL-1 beta in eosinophil-mediated small intestinal homeostasis and IgA production | * |
dc.type | Article | * |
dc.relation.issue | 4 | * |
dc.relation.volume | 8 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 930 | * |
dc.relation.lastpage | 942 | * |
dc.relation.journaltitle | MUCOSAL IMMUNOLOGY | * |
dc.identifier.doi | 10.1038/mi.2014.123 | * |
dc.identifier.wosid | WOS:000356865700021 | * |
dc.author.google | Jung, Y. | * |
dc.author.google | Wen, T. | * |
dc.author.google | Mingler, M. K. | * |
dc.author.google | Caldwell, J. M. | * |
dc.author.google | Wang, Y. H. | * |
dc.author.google | Chaplin, D. D. | * |
dc.author.google | Lee, E. H. | * |
dc.author.google | Jang, M. H. | * |
dc.author.google | Woo, S. Y. | * |
dc.author.google | Seoh, J. Y. | * |
dc.author.google | Miyasaka, M. | * |
dc.author.google | Rothenberg, M. E. | * |
dc.contributor.scopusid | 서주영(6603709174;57209001625) | * |
dc.contributor.scopusid | 우소연(7402853365) | * |
dc.date.modifydate | 20240118164942 | * |