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Association of Vac A- and Cag A-specific Helicobacter pylori strain infection with spontaneous preterm birth

Title
Association of Vac A- and Cag A-specific Helicobacter pylori strain infection with spontaneous preterm birth
Authors
Yang, Seung WooKwon, Han SungSohn, In SookKim, Young JuHwang, Han Sung
Ewha Authors
김영주
SCOPUS Author ID
김영주scopus
Issue Date
2017
Journal Title
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE
ISSN
1476-7058JCR Link

1476-4954JCR Link
Citation
JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE vol. 30, no. 8, pp. 995 - 1000
Keywords
Helicobacter pylori seropositivityhighly sensitive C-reactive proteinspontaneous preterm birth
Publisher
TAYLOR &

FRANCIS LTD
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
Purpose: To better understand the correlation between Helicobacter pylori (H. pylori) seropositivity and spontaneous preterm birth.Materials and methods: A total of 320 pregnant women were classified into two groups: normal control singleton pregnant group (n=264) and singleton spontaneous preterm birth group (n=56). Blood samples were collected at the time of delivery, and the H. pylori IgG, various virulence factors and systemic inflammation status were compared between the two groups.Results: Between the two groups, the serum H. pylori IgG, Cytotoxin-associated agntigen A (Cag A), Vacuolating cytotoxin A (Vac A) significantly increased in spontaneous preterm birth group than in the control group. Also, in preterm group, highly sensitive C-reactive protein (hsCRP) as a systemic inflammatory marker is statistically elevated at inflammatory status range. Whereas in the term pregnant group, hsCRP was normal range even though high incidence of H. pylori IgG seropositivity. Also, in the seropositive group, hsCRP is statistically correlated with H. pylori IgG, Cag A and Vac A.Conclusions: There is an association between the presence of antibodies against H. pylori in maternal serum and the development of preterm birth. Furthermore, serology type of H. pylori with Vac A, Cag A relates to preterm birth even though high H. pylori prevalence rate.
DOI
10.1080/14767058.2016.1196663
Appears in Collections:
의과대학 > 의학과 > Journal papers
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