Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 남상집 | * |
dc.date.accessioned | 2019-11-05T16:30:15Z | - |
dc.date.available | 2019-11-05T16:30:15Z | - |
dc.date.issued | 2019 | * |
dc.identifier.issn | 0022-3263 | * |
dc.identifier.issn | 1520-6904 | * |
dc.identifier.other | OAK-25570 | * |
dc.identifier.uri | https://dspace.ewha.ac.kr/handle/2015.oak/251775 | - |
dc.description.abstract | Glutamate neurotoxicity has been implicated in neuronal death in both acute CNS injury and in chronic neurodegenerative diseases. Five unique cyclic depsipeptides with neuroprotective activity, colletotrichamides A-E (1-5), were isolated from cultures of a halophyte Suaeda japonica-associated fungus, Colletotrichum gloeosporioides JS419. Spectroscopic analysis revealed that they were glycosylated cyclic lipodepsipeptides. Their relative configurations were determined by ROESY and J-based configuration analysis, and absolute configurations were established by chemical reactions including modified Mosher's method, advanced Marfey's method, and sugar derivatization. This is the first report of a glycosylated dimethyl-trioxygenated dodecanoyl moiety, and the relative as well as absolute stereochemistry was elucidated herein for the first time. Colletotrichamide C exhibited strong neuroprotective activity against glutamate in hippocampal HT22 cells. | * |
dc.language | English | * |
dc.publisher | AMER CHEMICAL SOC | * |
dc.title | Neuroprotective Glycosylated Cyclic Lipodepsipeptides, Colletotrichamides A-E, from a Halophyte-Associated Fungus, Colletotrichum gloeosporioides JS419 | * |
dc.type | Article | * |
dc.relation.issue | 17 | * |
dc.relation.volume | 84 | * |
dc.relation.index | SCIE | * |
dc.relation.index | SCOPUS | * |
dc.relation.startpage | 10999 | * |
dc.relation.lastpage | 11006 | * |
dc.relation.journaltitle | JOURNAL OF ORGANIC CHEMISTRY | * |
dc.identifier.doi | 10.1021/acs.joc.9b01511 | * |
dc.identifier.wosid | WOS:000485089200043 | * |
dc.author.google | Bang, Sunghee | * |
dc.author.google | Lee, Changyeol | * |
dc.author.google | Kim, Soonok | * |
dc.author.google | Song, Ji Hoon | * |
dc.author.google | Kang, Ki Sung | * |
dc.author.google | Deyrup, Stephen T. | * |
dc.author.google | Nam, Sang-Jip | * |
dc.author.google | Xia, Xuekui | * |
dc.author.google | Shim, Sang Hee | * |
dc.contributor.scopusid | 남상집(57208839798) | * |
dc.date.modifydate | 20240220120010 | * |