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Water-Soluble Phthalocyanines Selectively Bind to Albumin Dimers: A Green Approach Toward Enhancing Tumor-Targeted Photodynamic Therapy

Title
Water-Soluble Phthalocyanines Selectively Bind to Albumin Dimers: A Green Approach Toward Enhancing Tumor-Targeted Photodynamic Therapy
Authors
Li, XingshuJeong, KeunsooLee, YoonjiGuo, TianLee, DayoungPark, JeongminKwon, NahyunNa, Jung-HyunHong, Seung KonCha, Sun-ShinHuang, Jian-DongChoi, SunKim, SehoonYoon, Juyoung
Ewha Authors
윤주영최선이윤지차선신
SCOPUS Author ID
윤주영scopus; 최선scopus; 이윤지scopus; 차선신scopus
Issue Date
2019
Journal Title
THERANOSTICS
ISSN
1838-7640JCR Link
Citation
THERANOSTICS vol. 9, no. 22, pp. 6412 - 6423
Keywords
photodynamic therapyphthalocyaninealbumin dimernatural carriertumor targeting
Publisher
IVYSPRING INT PUBL
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
Targeted delivery of therapeutic agents is of particular interest in the field of cancer treatment. However, there is an urgent need for developing clinically promising targeting approaches that can be readily administered in a green manner. Methods: Five phthalocyanine derivatives bearing different anionic and cationic groups were designed and synthesized. Then, their binding affinity with albumin were studied using gel assays, optical spectra and computational simulation. Finally, in vitro and in vivo fluorescence imaging and photodynamic therapy (PDT) evaluations were carried out. Results: The two positively charged compounds could selectively bind to albumin dimer over albumin monomer, while the three negatively charged phthalocyanines could bind to both albumin monomer and dimer. Following systemic administration, the phthalocyanines show improved tumor accumulation via transport by natural albumin. PDT evaluations indicate that one of the positively charged compounds, ZnPcN4, shows outstanding phototherapeutic efficacy against tumors in preclinical models. Conclusion: Our findings demonstrate that the use of water-soluble phthalocyanines as photosensitizers and in vivo albumin as a natural carrier may provide a green and efficient approach for tumor-targeted imaging and therapy.
DOI
10.7150/thno.35210
Appears in Collections:
자연과학대학 > 화학·나노과학전공 > Journal papers
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