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Synthesis of 1,2,3-Triazolium Ionic Liquid-Supported Chiral Imidazolidinones and Their Application in Asymmetric Alkylation Reaction
- Title
- Synthesis of 1,2,3-Triazolium Ionic Liquid-Supported Chiral Imidazolidinones and Their Application in Asymmetric Alkylation Reaction
- Authors
- Jeong, Yunkyung; Park, Yunjeong; Ryu, Jae-Sang
- Ewha Authors
- 류재상; 박윤정
- SCOPUS Author ID
- 류재상; 박윤정
- Issue Date
- 2019
- Journal Title
- MOLECULES
- ISSN
- 1420-3049
- Citation
- MOLECULES vol. 24, no. 18
- Keywords
- ionic liquid; 1,2,3-triazolium; chiral imidazolidinone; asymmetric alkylation; chiral auxiliaries
- Publisher
- MDPI
- Indexed
- SCIE; SCOPUS
- Document Type
- Article
- Abstract
- New 1,2,3-triazolium ionic liquid-supported chiral imidazolidinones were developed. The feasibility of the ionic liquid-supported imidazolidinones as chiral auxiliaries was demonstrated in sequential propionylation-alkylation-cleavage reactions, which provided the chiral product with good to excellent chemical yields (up to 90%) and high selectivities (up to 94% ee). The progress of the reactions could be monitored by TLC and NMR, and the ionic liquid-supported chiral auxiliaries could be recovered by simple extraction.
- DOI
- 10.3390/molecules24183349
- Appears in Collections:
- 약학대학 > 약학과 > Journal papers
- Files in This Item:
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