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Chronological View of Peak and Diphasic Dyskinesia, Wearing Off and Freezing of Gait in Parkinson's Disease

Title
Chronological View of Peak and Diphasic Dyskinesia, Wearing Off and Freezing of Gait in Parkinson's Disease
Authors
Kim, Young EunJeon, BeomseokYun, Ji YoungYang, Hui-JunKim, Han-Joon
Ewha Authors
윤지영
Issue Date
2019
Journal Title
JOURNAL OF PARKINSONS DISEASE
ISSN
1877-7171JCR Link

1877-718XJCR Link
Citation
JOURNAL OF PARKINSONS DISEASE vol. 9, no. 4, pp. 741 - 747
Publisher
IOS PRESS
Indexed
SCIE; SCOPUS WOS
Document Type
Article
Abstract
Background: Dyskinesia, wearing off (WO) and freezing of gait (FOG) are troublesome complications degrading quality of life in the course of Parkinson's disease (PD). Objective: This study evaluated the gross chronological trend of 4 motor complications - peak dose dyskinesia (PDSK), diphasic dyskinesia (DDSK), WO and FOG in a large PD population with stratification by age at disease onset according to the PD duration. Methods: The motor complications of 1212 Korean PD patients were analyzed using Kaplan-Meier curves and Cox proportional hazards models. Results: PDSK and WO appeared first as motor complications and showed accelerated development around the 5 year-PD-duration, while DDSK showed a rather constant development over time and FOG developed around the 10 year-disease duration at an accelerated rate (p < 0.001). A younger age at PD onset predicted an earlier appearance of PDSK, DDSK and WO (p < 0.001), while an older age at onset (>= 60 years) was a predictor for FOG (p = 0.014). Conclusion: Motor complications developed with a distinguishing inclination over the PD duration. This study provides insight into the chronological trend of motor complications in PD at a glance.
DOI
10.3233/JPD-191624
Appears in Collections:
의과대학 > 의학과 > Journal papers
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