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Transcription-dependent targeting of Hda1C to hyperactive genes mediates H4-specific deacetylation in yeast

Title
Transcription-dependent targeting of Hda1C to hyperactive genes mediates H4-specific deacetylation in yeast
Authors
Ha S.D.Ham S.Kim M.Y.Kim J.H.Jang I.Lee B.B.Lee M.K.Hwang J.-T.Roh T.-Y.Kim T.S.
Ewha Authors
김태수
SCOPUS Author ID
김태수scopus
Issue Date
2019
Journal Title
Nature Communications
ISSN
2041-1723JCR Link
Citation
Nature Communications vol. 10, no. 1
Publisher
Nature Publishing Group
Indexed
SCIE; SCOPUS WOS scopus
Document Type
Article
Abstract
In yeast, Hda1 histone deacetylase complex (Hda1C) preferentially deacetylates histones H3 and H2B, and functionally interacts with Tup1 to repress transcription. However, previous studies identified global increases in histone H4 acetylation in cells lacking Hda1, a component of Hda1C. Here, we find that Hda1C binds to hyperactive genes, likely via the interaction between the Arb2 domain of Hda1 and RNA polymerase II. Additionally, we report that Hda1C specifically deacetylates H4, but not H3, at hyperactive genes to partially inhibit elongation. This role is contrast to that of the Set2–Rpd3S pathway deacetylating histones at infrequently transcribed genes. We also find that Hda1C deacetylates H3 at inactive genes to delay the kinetics of gene induction. Therefore, in addition to fine-tuning of transcriptional response via H3-specific deacetylation, Hda1C may modulate elongation by specifically deacetylating H4 at highly transcribed regions. © 2019, The Author(s).
DOI
10.1038/s41467-019-12077-w
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자연과학대학 > 생명과학전공 > Journal papers
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